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BIX-01294

Catalog No. T7697   CAS 935693-62-2

BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).

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BIX-01294 Chemical Structure
BIX-01294, CAS 935693-62-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 47.00
5 mg In stock $ 77.00
10 mg In stock $ 119.00
25 mg In stock $ 218.00
50 mg In stock $ 369.00
100 mg In stock $ 546.00
200 mg In stock $ 778.00
1 mL * 10 mM (in DMSO) In stock $ 133.00
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Purity: 99.31%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).
Targets&IC50 G9a:1.9 μM
In vitro BIX-01294 induced caspase-dependent apoptosis in human bladder cancer cells.?BIX-01294 stimulates endoplasmic reticulum stress (ER stress) and up-regulated expression of PMAIP1 through DDIT3 up-regulation.?Furthermore, down-regulation of the deubiquitinase USP9X by BIX-01294 results in downstream reduction of MCL1 expression, leading to apoptosis eventually[1].
Cell Research On the first day, cells were seeded in 96 well plates.?Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well.?After treatment by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1]
Molecular Weight 490.64
Formula C28H38N6O2
CAS No. 935693-62-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 98 mg/mL (163.33 mM)

TargetMolReferences and Literature

1. Cui J , Sun W , Hao X , et al. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells[J]. Cancer Cell International, 2015, 15(1):4. 2. Homon C A , O'Sullivan R , August E M , et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.[J]. Molecular Cell, 2007, 25(3):473-481. 3. Zhang Y, Xue W, Zhang W, et al. Histone methyltransferase G9a protects against acute liver injury through GSTP1[J]. Cell Death & Differentiation. 2020, 27(4): 1243-1258.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compound Library Epigenetics Compound Library Anti-Aging Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Autophagy Compound Library Inhibitor Library Histone Modification Compound Library Stem Cell Differentiation Compound Library

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CPI-360 CCI-007 JIB-04 EPZ020411 UNC0638 A-395 CPI-169 racemate UNC0642

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Keywords

BIX-01294 935693-62-2 Autophagy Chromatin/Epigenetic Histone Methyltransferase PRMT1 recurrent H3K9me3 Inhibitor Cdkn1a inhibit p53 Gadd45a MLKL BIX 01294 SUV39H1(H320R) H3K9me2 BIX01294 p21 inhibitor

 

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