Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 119.00 | |
25 mg | In stock | $ 218.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 546.00 | |
200 mg | In stock | $ 778.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). |
Targets&IC50 | G9a:1.9 μM |
In vitro | BIX-01294 induced caspase-dependent apoptosis in human bladder cancer cells.?BIX-01294 stimulates endoplasmic reticulum stress (ER stress) and up-regulated expression of PMAIP1 through DDIT3 up-regulation.?Furthermore, down-regulation of the deubiquitinase USP9X by BIX-01294 results in downstream reduction of MCL1 expression, leading to apoptosis eventually[1]. |
Cell Research | On the first day, cells were seeded in 96 well plates.?Twenty-four hours later, BIX-01294 was added at the indicated concentrations in each well.?After treatment by BIX-01294 for another 24 h, we used 10% TCA to immobilize the cells and then evaluated the living cell numbers using the sulforhodamine B assay as previously described[1] |
Molecular Weight | 490.64 |
Formula | C28H38N6O2 |
CAS No. | 935693-62-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 98 mg/mL (163.33 mM)
You can also refer to dose conversion for different animals. More
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BIX-01294 935693-62-2 Autophagy Chromatin/Epigenetic Histone Methyltransferase PRMT1 recurrent H3K9me3 Inhibitor Cdkn1a inhibit p53 Gadd45a MLKL BIX 01294 SUV39H1(H320R) H3K9me2 BIX01294 p21 inhibitor