g-quadruplex — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T18883	2-Di-1-ASP		Others
	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.		Others
T4470	Pyridostatin TFA		DNA/RNA Synthesis
	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.		DNA/RNA Synthesis
T60028	MM41		DNA/RNA Synthesis
	MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line.		DNA/RNA Synthesis
T7409	360A		DNA/RNA Synthesis , Telomerase
	360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).		DNA/RNA Synthesis , Telomerase
T13174	TMPyP4 tosylate	TMP 1363	DNA/RNA Synthesis , Telomerase
	TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.		DNA/RNA Synthesis , Telomerase
T74613	G-quadruplex DNA fluorescence probe 1
	Compound E1, also known as G-quadruplex DNA fluorescence probe 1, is a selective fluorescent probe targeting G-quadruplex DNA. It possesses the ability to penetrate membranes and enter living cells, demonstrating low cyt...
T1899	Pyridostatin	RR82,Pyridostatin Trifluoroacetate Salt	DNA/RNA Synthesis
	Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres.		DNA/RNA Synthesis
T13584	BMVC-8C3O		DNA/RNA Synthesis
	BMVC-8C3O, a DNA G-quadruplex (G4) ligand, induces the topological conversion from non-parallel to parallel forms in human telomeric DNA G4s.		DNA/RNA Synthesis
T10352	APTO-253	LOR-253,LT-253	Apoptosis , c-Myc , KLF
	APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the K...		Apoptosis , c-Myc , KLF
T16703	Quarfloxin	CX-3543	DNA/RNA Synthesis
	Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-...		DNA/RNA Synthesis
T5S2361	Epiberberine		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
T10574	BMVC		Telomerase
	BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).		Telomerase
T30745	Carboxy-pyridostatin
	Carboxy-pyridostatin, as a fluorescent probe, can target G-quadruplex structures and trap cytoplasmic RNA G-quadruplex structures in cells.
T19212	BMVC2	o-BMVC	Others
	BMVC2 (o-BMVC), a carbazole derivative of BMVC, is a G-quadruplex (G4) stabilizer.		Others
T26892	Braco-19
	Braco-19 is a G-quadruplex ligand, it inhibits the growth of tumor.
T32014	GTC365	GTC 365,NSC 177365,GTC-365,NSC-177365,NSC177365
	GTC365 is an hTERT transcriptional repressor that acts in the early stages of the G-quadruplex folding pathway.
T28942	Telomestatin	SOT 095,GM95,(R)-Telomestatin,GM 95,GM-95
	Telomestatin is an inhibitor of the telomerase, it induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region.
T13504	360A iodide	360 A iodide	Telomerase
	360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).		Telomerase
T13817	Phen-DC3		Others
	Phen-DC3 is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases (IC50s of 65±6 and 50±10 nM, respectively).		Others
T25255	CL67	CL-67,CL 67
	CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.