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Quarfloxin

Catalog No. T16703 CAS 865311-47-3

Synonyms: CX-3543

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.

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Quarfloxin, CAS 865311-47-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 122.00
5 mg	In stock	$ 268.00
10 mg	In stock	$ 428.00
25 mg	In stock	$ 688.00
50 mg	In stock	$ 969.00
100 mg	In stock	$ 1,230.00
1 mL * 10 mM (in DMSO)	In stock	$ 362.00

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Purity: 99.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.
In vitro	Quarfloxin effectively inhibits the growth of neuroblastoma cells in vitro. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].

Synonyms	CX-3543
Molecular Weight	604.67
Formula	C35H33FN6O3
CAS No.	865311-47-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (90.96 mM)

H2O: 1 mg/mL (1.65 mM), when pH is adjusted to 5 with 0.1 M HCl. Sonication is recommended.

References and Literature

1. Hald ØH, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Drug Library Bioactive Compounds Library Max Clinical Compound Library Hematonosis Compound Library NO PAINS Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Quarfloxin 865311-47-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibit Inhibitor CX-3543 CX3543 CX 3543 inhibitor

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