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Braco-19

Catalog No. T26892 CAS 351351-75-2

Braco-19 is a telomerase/telomere inhibitor with anti-HIV-1 activity.Braco-19 is a quaternary (GQ)-binding ligand that inhibits tumor growth and inhibits apoptosis.Braco-19 is also a HAdV viral replication inhibitor and is used in the study of HIV infections and human herpesvirus infections.

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Braco-19, CAS 351351-75-2

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Braco-19 is a telomerase/telomere inhibitor with anti-HIV-1 activity.Braco-19 is a quaternary (GQ)-binding ligand that inhibits tumor growth and inhibits apoptosis.Braco-19 is also a HAdV viral replication inhibitor and is used in the study of HIV infections and human herpesvirus infections.
In vitro	In HEK 293 cells, Braco-19 (20 μM; 40 μM; 24 hours) displayed low cytotoxicity and decreased the eGFP fluorescence[1].
In vivo	In nude mice bearing established UXF1138LX xenografts, Braco-19 (2 mg/kg; intraperitoneal injection; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments) exhibited partial tumor regression, with an optimal T/C of 4.1% on day 28, representing a 95.9% inhibition of tumor growth compared to the control[1].

Molecular Weight	593.76
Formula	C35H43N7O2
CAS No.	351351-75-2

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (33.68 mM), Sonication is recommended.

References and Literature

1. Angelika M Burger, et al. The G-quadruplex-interactive Molecule BRACO-19 Inhibits Tumor Growth, Consistent With Telomere Targeting and Interference With Telomerase Function. Cancer Res. 2005 Feb 15;65(4):1489-96. 2. Majee P, et al. Genome-wide analysis reveals a regulatory role for G-quadruplexes during Adenovirus multiplication. Virus Res. 2020 Jul 2;283:197960. 3. Shitikov E, et al. Genome-Wide Transcriptional Response of Mycobacterium smegmatis MC2155 to G-Quadruplex Ligands BRACO-19 and TMPyP4. Front Microbiol. 2022 Mar 4;13:817024. 4. Zhou G, et al. Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells. Oncotarget. 2016 Mar 22;7(12):14925-39.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Braco-19 351351-75-2 Apoptosis DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome HIV Protease Telomerase Braco19 Braco 19 inhibitor inhibit

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