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Search Result

Search Results for " fgfr4 "

Targets

FGFR

39

Compounds

20

Recombinant Proteins

Cat No. Product Name Synonyms Targets
TQ0256 FGFR4-IN-1 FGFR
FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).
T37425 FGFR4-IN-5 FGFR4-IN-5
FGFR4-IN-5, a covalent FGFR4 inhibitor, demonstrates potency and selectivity with an IC50 value of 6.5 nM. Exhibiting significant in vivo anti-tumor activity, it is applicable for research in hepatocellular carcinoma [1]...
T11280 FGFR4-IN-4 FGFR
FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.
T73121 FGFR4-IN-8 FGFR
FGFR4-IN-8 (Compound 7v) is an ATP-competitive inhibitor that covalently and highly selectively targets both the wild-type and gatekeeper mutant forms of FGFR4. It shows excellent inhibitory potency with IC50s of 0.5 nM ...
T63662 FGFR4-IN-9
FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.
T79271 FGFR4-IN-14 FGFR
FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutant strains. Specifically, it registers IC50 values of 21 nM aga...
T63704 FGFR4-IN-11
FGFR4-IN-11 is a selective, potent, covalently bound FGFR4 inhibitor (IC50: 2.1 nM). FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and exhibits anticancer effects.
T63692 FGFR4-IN-7
FGFR4-IN-7 is a covalent, reversible FGFR4 inhibitor (IC50: 0.42 μM) that blocks the FGFR4 signaling pathway, thereby inducing apoptosis.
T62682 FGFR4-IN-10
FGFR4-IN-10 (compound 5a) is a selective and potent inhibitor of FGFR4 (IC50: 70.7 nM).FGFR4-IN-10 does not inhibit other FGFR family members (i.e., FGFR1, FGFR2, and FGFR3).
T64015 FGFR4-IN-6
FGFR4-IN-6 is a covalent, reversible FGFR4 inhibitor (IC50: 5.4 nM) that exhibits good oral pharmacokinetic properties. In a xenograft mouse model of the Hep3B2.1-7 HCC cell line, FGFR4-IN-6 was able to significantly ind...
T79880 FGFR4-IN-16 FGFR
FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].
T4235 Roblitinib FGF-401 FGFR
Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads ...
T3456 Fisogatinib BLU554,BLU 554,BLU-554 FGFR
Fisogatinib (BLU-554) is a potent inhibitor of fibroblast growth factor receptor 4 (FGFR4).
T37426 FIIN-1 FGFR irreversible inhibitor-1 FGFR
FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FIIN-1 inhibited FGFR1, FGFR2,...
T2347 BLU9931 FGFR
BLU9931 is the first selective small molecule inhibitor of FGFR4.
T6024 Zoligratinib FF284,CH5183284,Debio 1347 FGFR
Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively.
T7738 H3B-6527 FGFR
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.
T12401 Pemigatinib INCB054828 FGFR
Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).
T16364 Infigratinib phosphate NVP-BGJ398 phosphate,BGJ-398 phosphate FGFR
Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
T1975 Infigratinib BGJ-398,NVP-BGJ398 Apoptosis , FGFR
Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and VEGFR2.
T3466 FIIN-3 EGFR , FGFR
FIIN-3 is an irreversible inhibitor of FGFR.
T2361 LY2874455 LY 2874455,LY-2874455 VEGFR , FGFR
LY2874455 has been used in trials studying the treatment of Advanced Cancer.
T6836 FIIN-2 FGFR
FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.
T1948 AZD4547 VEGFR , FGFR
AZD4547, a new-type specific FGFR inhibitor, targets for FGFR1/2/3 (IC50: 0.2/2.5/1.8 nM in cell-free assays).
TQ0015 PRN1371 c-Fms , FGFR , CSF-1R
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
T5473 ASP5878 ASP-5878 FGFR
ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.
T79257 FGFR-IN-11 FGFR
FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhi...
T3726 Erdafitinib JNJ-42756493 Apoptosis , FGFR
Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.
T70258 Roblitinib citrate
Roblitinib citrate is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4) with potential antineoplastic activity.
T79850 Irpagratinib ABSK011 FGFR
Irpagratinib (ABSK011) is an orally active fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor with specificity for FGFR4, exhibiting an IC50 of less than 10 nM. It effectively inhibits FGFR4 auto-phosphor...
T73316 FGFR-IN-9
FGFR-IN-9 is a potent, reversible, and orally active inhibitor of the fibroblast growth factor receptor (FGFR) family, demonstrating IC50 values of 17.1 nM for FGFR4 WT, 29.6 nM for FGFR3, 30.7 nM for FGFR4 V550L, 46.7 n...
T72749 E7090 succinate
E7090 succinate is a selective, potent, orally-administered inhibitor of FGFR1, FGFR2, and FGFR3 tyrosine kinase activities, demonstrating IC50 values of 0.71 nM (FGFR1), 0.50 nM (FGFR2), 1.2 nM (FGFR3), and 120 nM (FGFR...
T62653 FGFR-IN-2
FGFR-IN-2 (compound 1) is a potent inhibitor of FGFR, acting on FGFR1 (IC50: 7.3 nM), FGFR2 (IC50: 4.3 nM), FGFR3 (IC50: 7.6 nM) and FGFR4 (IC50: 11 nM).
T79871 S6K2-IN-1 FGFR
S6K2-IN-1 (Compound 2) is an inhibitor of S6K2 with an IC50 of 22 nM and also exhibits inhibitory activity against FGFR4 with an IC50 of 216 nM. This compound demonstrates acceptable stability in mouse liver microsomes [...
T73179 HDAC-IN-50
HDAC-IN-50, a potent, orally active inhibitor targeting both FGFR (Fibroblast Growth Factor Receptor) and HDAC (Histone Deacetylase), exhibits IC50 values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, F...
T7611 ODM-203 VEGFR , FGFR
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
T83911 CYY292
CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM. It exhibits selectivity over FGFR4 (IC50 > 1,000 nM) while also targ...
T5044 Futibatinib TAS120,FGFR-IN-1 FGFR
Futibatinib (FGFR-IN-1) is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.
T27234 E7090 E-7090,E 7090
E-7090 is a fibroblast growth factor receptor inhibitor. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3.

Compounds

FGFR4-IN-1
TQ0256
Synonym:
Target: FGFR
FGFR4-IN-5
T37425
Synonym: FGFR4-IN-5
Target:
FGFR4-IN-4
T11280
Synonym:
Target: FGFR
FGFR4-IN-8
T73121
Synonym:
Target: FGFR
FGFR4-IN-9
T63662
Synonym:
Target:
FGFR4-IN-14
T79271
Synonym:
Target: FGFR
FGFR4-IN-11
T63704
Synonym:
Target:
FGFR4-IN-7
T63692
Synonym:
Target:
FGFR4-IN-10
T62682
Synonym:
Target:
FGFR4-IN-6
T64015
Synonym:
Target:
FGFR4-IN-16
T79880
Synonym:
Target: FGFR
Roblitinib
T4235
Synonym: FGF-401
Target: FGFR
Fisogatinib
T3456
Synonym: BLU554,BLU 554,BLU-554
Target: FGFR
FIIN-1
T37426
Synonym: FGFR irreversible inhibitor-1
Target: FGFR
BLU9931
T2347
Synonym:
Target: FGFR
Zoligratinib
T6024
Synonym: FF284,CH5183284,Debio 1347
Target: FGFR
H3B-6527
T7738
Synonym:
Target: FGFR
Pemigatinib
T12401
Synonym: INCB054828
Target: FGFR
Infigratinib phosphate
T16364
Synonym: NVP-BGJ398 phosphate,BGJ-398 phosphate
Target: FGFR
Infigratinib
T1975
Synonym: BGJ-398,NVP-BGJ398
Target: Apoptosis, FGFR
FIIN-3
T3466
Synonym:
Target: EGFR, FGFR
LY2874455
T2361
Synonym: LY 2874455,LY-2874455
Target: VEGFR, FGFR
FIIN-2
T6836
Synonym:
Target: FGFR
AZD4547
T1948
Synonym:
Target: VEGFR, FGFR
PRN1371
TQ0015
Synonym:
Target: c-Fms, FGFR, CSF-1R
ASP5878
T5473
Synonym: ASP-5878
Target: FGFR
FGFR-IN-11
T79257
Synonym:
Target: FGFR
Erdafitinib
T3726
Synonym: JNJ-42756493
Target: Apoptosis, FGFR
Roblitinib citrate
T70258
Synonym:
Target:
Irpagratinib
T79850
Synonym: ABSK011
Target: FGFR
FGFR-IN-9
T73316
Synonym:
Target:
E7090 succinate
T72749
Synonym:
Target:
FGFR-IN-2
T62653
Synonym:
Target:
S6K2-IN-1
T79871
Synonym:
Target: FGFR
HDAC-IN-50
T73179
Synonym:
Target:
ODM-203
T7611
Synonym:
Target: VEGFR, FGFR
CYY292
T83911
Synonym:
Target:
Futibatinib
T5044
Synonym: TAS120,FGFR-IN-1
Target: FGFR
E7090
T27234
Synonym: E-7090,E 7090
Target:

Recombinant Proteins

Species：
Human (10)
Rhesus (3)
Chicken (2)
Mouse (2)
Rat (2)
Rabbit (1)
Expression System：
HEK293 Cells (14)
E. coli (4)
Baculovirus Insect Cells (1)
P. pastoris (Yeast) (1)
Tag：
C-His-Avi (4)
C-His (3)
His (3)
Tag Free (2)
hFc (2)
C-hFc (1)
His, GST (1)
His, hFc (1)
N-10xHis, C-Myc (1)
N-6xHis (1)
Cat No. Product Name Species Expression System
TMPK-00378 FGFR4 beta Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
FGFR4 beta Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.90 kDa and the accession number is P22455-1.
TMPY-02112 FGFR4 Protein, Human, Recombinant (His) Human HEK293 Cells
FGFR4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
TMPK-00380 FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.90 kDa and the accession number is P22455-1.
TMPK-01322 FGFR4 Protein, Rhesus macaque, Recombinant (His) Rhesus HEK293 Cells
FGFR4 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.66 kDa and the accession number is XP_028705775.1.
TMPK-00379 FGFR4 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
FGFR4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
TMPK-00381 FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.4 kDa and the accession number is P22455-1.
TMPY-00806 FGFR4 Protein, Human, Recombinant (hFc) Human HEK293 Cells
FGFR4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is P22455-1.
TMPY-03322 FGFR4 Protein, Rhesus, Recombinant (hFc) Rhesus HEK293 Cells
FGFR4 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.6 kDa and the accession number is XP_001087243.1.
TMPY-03683 FGFR4 Protein, Rhesus, Recombinant (His) Rhesus HEK293 Cells
FGFR4 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.8 kDa and the accession number is XP_001087243.1.
TMPY-02862 FGFR4 Protein, Rat, Recombinant (His) Rat HEK293 Cells
FGFR4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.3 kDa and the accession number is Q498D6.
TMPY-00974 FGFR4 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
FGFR4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is A0A0R4IZY3.
TMPY-02635 FGFR4 Protein, Rat, Recombinant (hFc) Rat HEK293 Cells
FGFR4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 66 kDa and the accession number is Q498D6.
TMPY-01019 FGFR4 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293 Cells
FGFR4 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 67 kDa and the accession number is A0A0R4IZY3.
TMPY-06037 FGFR4 Protein, Human, Recombinant (His), Biotinylated Human HEK293 Cells
FGFR4 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22455-1.
TMPY-02907 FGF-19 Protein, Human, Recombinant Human E. coli
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inclu...
TMPY-03104 FGF-17 Protein, Human, Recombinant Human E. coli
FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including ...
TMPH-00368 FGF-2 Protein, Chicken, Recombinant (His) Chicken P. pastoris (Yeast)
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation an...
TMPH-00369 FGF-2 Protein, Chicken, Recombinant (His & Myc) Chicken E. coli
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation an...
TMPH-03203 FGFb Protein, Rabbit, Recombinant (His & SUMO) Rabbit E. coli
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell di...
TMPY-02240 STAT1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate t...
FGFR4 beta Protein, Human, Recombinant (His & Avi)
TMPK-00378
Species: Human
Expression System: HEK293 Cells
FGFR4 Protein, Human, Recombinant (His)
TMPY-02112
Species: Human
Expression System: HEK293 Cells
FGFR4 beta Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00380
Species: Human
Expression System: HEK293 Cells
FGFR4 Protein, Rhesus macaque, Recombinant (His)
TMPK-01322
Species: Rhesus
Expression System: HEK293 Cells
FGFR4 Protein, Human, Recombinant (His & Avi)
TMPK-00379
Species: Human
Expression System: HEK293 Cells
FGFR4 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00381
Species: Human
Expression System: HEK293 Cells
FGFR4 Protein, Human, Recombinant (hFc)
TMPY-00806
Species: Human
Expression System: HEK293 Cells
FGFR4 Protein, Rhesus, Recombinant (hFc)
TMPY-03322
Species: Rhesus
Expression System: HEK293 Cells
FGFR4 Protein, Rhesus, Recombinant (His)
TMPY-03683
Species: Rhesus
Expression System: HEK293 Cells
FGFR4 Protein, Rat, Recombinant (His)
TMPY-02862
Species: Rat
Expression System: HEK293 Cells
FGFR4 Protein, Mouse, Recombinant (His)
TMPY-00974
Species: Mouse
Expression System: HEK293 Cells
FGFR4 Protein, Rat, Recombinant (hFc)
TMPY-02635
Species: Rat
Expression System: HEK293 Cells
FGFR4 Protein, Mouse, Recombinant (His & hFc)
TMPY-01019
Species: Mouse
Expression System: HEK293 Cells
FGFR4 Protein, Human, Recombinant (His), Biotinylated
TMPY-06037
Species: Human
Expression System: HEK293 Cells
FGF-19 Protein, Human, Recombinant
TMPY-02907
Species: Human
Expression System: E. coli
FGF-17 Protein, Human, Recombinant
TMPY-03104
Species: Human
Expression System: E. coli
FGF-2 Protein, Chicken, Recombinant (His)
TMPH-00368
Species: Chicken
Expression System: P. pastoris (Yeast)
FGF-2 Protein, Chicken, Recombinant (His & Myc)
TMPH-00369
Species: Chicken
Expression System: E. coli
FGFb Protein, Rabbit, Recombinant (His & SUMO)
TMPH-03203
Species: Rabbit
Expression System: E. coli
STAT1 Protein, Human, Recombinant (His & GST)
TMPY-02240
Species: Human
Expression System: Baculovirus Insect Cells
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