Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 81.00 | |
2 mg | In stock | $ 138.00 | |
5 mg | In stock | $ 191.00 | |
10 mg | In stock | $ 332.00 | |
25 mg | In stock | $ 558.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,120.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 297.00 |
Description | H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity. |
In vitro | H3B-6527, a highly selective covalent FGFR4 inhibitor, through structure-guided drug design. Studies in a panel of 40 HCC cell lines and 30 HCC PDX models showed that FGF19 expression is a predictive biomarker for H3B-6527 response. Moreover, coadministration of the CDK4/6 inhibitor palbociclib in combination with H3B-6527 could effectively trigger tumor regression in a xenograft model of HCC[1].?FGFR4 is frequently overexpressed in ESCC tissue and cell lines. in vitro assays have shown that blocking FGFR4 by a specific blocker, H3B-6527, significantly decreases proliferation, invasion, and migration, and alters epithelial-mesenchymal transition markers in ESCC cells. In addition, FGFR4 blockade is associated with the induction of apoptosis and affects PI3K/Akt and MAPK/ERK pathways[2]. |
Cell Research | Immunohistochemistry and Western blotting were used to detect FGFR4 expression in ESCC samples and cell lines. Cell counting kit-8, and clonogenic, transwell, flow cytometric, and tumor xenograft in nude mice assays were utilized to determine the effect of blocking FGFR4 in proliferation, invasion, migration, and apoptosis of ESCC cells[2]. |
Molecular Weight | 629.54 |
Formula | C29H34Cl2N8O4 |
CAS No. | 1702259-66-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.3 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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H3B-6527 1702259-66-2 Angiogenesis Tyrosine Kinase/Adaptors FGFR H3B6527 H-3B-6527 H3B 6527 inhibitor inhibit