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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11212 | EPAC 5376753 | 5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | cAMP |
EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 µM in Swiss 3T3 cells. | |||
T11234 | ESI-08 | cAMP | |
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation. | |||
T27635 | Isoxepac | Olopatadine USP Related Compound C | Others |
Isoxepac (Olopatadine USP Related Compound C) is a non-steroidal anti-antiphlogistic agent and analgesic. | |||
T38815 | Millepachine | Apoptosis | |
Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells. | |||
T3548 | Epacadostat | INCB 024360,IDO Inhibitor 1 | IDO , Indoleamine 2,3-Dioxygenase (IDO) |
Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells. | |||
T24449 | Mepacrine | Haffkinine,Erion | Others |
Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial. It is used in cell biological experiments as an inhibitor of phospholipase A2. | |||
T82461 | Epacmarstobart | GS-0189,FSI-189 | |
Epacmarstobart (FSI-189; GS-0189) is a chimeric humanized IgG1κ antibody designed to target the mouse Signal Regulatory Protein Alpha (SIRPA). | |||
T2244 | ESI-09 | cAMP , Virus Protease | |
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively. | |||
T15485 | HJC0197 | cAMP , Ras | |
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2). | |||
T67965 | Torbafylline | cAMP , PI3K , PDE | |
Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits t... | |||
T22536 | 8-pCPT-2-O-Me-cAMP-AM | Others | |
Epac activator | |||
T70173 | NY0123 | ||
NY0123 is an active EPAC antagonist with low micromolar inhibitory activity. | |||
T22014 | 8-CPT-2Me-cAMP, sodium salt | ||
8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac). These Epac proteins are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for act... | |||
T21705 | 8-CPT-Cyclic AMP (sodium salt) | ||
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium functions dually as a selective activator of cyclic AMP-dependent protein kinase (PKA) and as a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA), demonstrating a... |