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Search Results for " epac "

14

Compounds

Cat No. Product Name Synonyms Targets
T11212 EPAC 5376753 5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-thioxodihydropyrimidine-4,6(1H,5H)-dione cAMP
EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 µM in Swiss 3T3 cells.
T11234 ESI-08 cAMP
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
T27635 Isoxepac Olopatadine USP Related Compound C Others
Isoxepac (Olopatadine USP Related Compound C) is a non-steroidal anti-antiphlogistic agent and analgesic.
T38815 Millepachine Apoptosis
Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.
T3548 Epacadostat INCB 024360,IDO Inhibitor 1 IDO , Indoleamine 2,3-Dioxygenase (IDO)
Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune cells and reducing tumor-associated regulatory T cells.
T24449 Mepacrine Haffkinine,Erion Others
Mepacrine (Erion) is an acridine derivative formerly widely used as an antimalarial. It is used in cell biological experiments as an inhibitor of phospholipase A2.
T82461 Epacmarstobart GS-0189,FSI-189
Epacmarstobart (FSI-189; GS-0189) is a chimeric humanized IgG1κ antibody designed to target the mouse Signal Regulatory Protein Alpha (SIRPA).
T2244 ESI-09 cAMP , Virus Protease
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
T15485 HJC0197 cAMP , Ras
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).
T67965 Torbafylline cAMP , PI3K , PDE
Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits t...
T22536 8-pCPT-2-O-Me-cAMP-AM Others
Epac activator
T70173 NY0123
NY0123 is an active EPAC antagonist with low micromolar inhibitory activity.
T22014 8-CPT-2Me-cAMP, sodium salt
8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac). These Epac proteins are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for act...
T21705 8-CPT-Cyclic AMP (sodium salt)
8-CPT-Cyclic AMP (8-CPT-cAMP) sodium functions dually as a selective activator of cyclic AMP-dependent protein kinase (PKA) and as a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA), demonstrating a...
TargetMol