egfr-in-50 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63996	EGFR-IN-50
	EGFR-IN-50 is a potent EGFR inhibitor targeting L858R resistance mutations, acting on TEL-EGFR-L858R-BaF3 and TEL-EGFR-T790M-L858R-BaF3 with GI50 values of 8 nM and 6.03 μM, respectively. EGFR-IN-50 exhibits anti-prolife...
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-f...
T61225	EGFR-IN-64
	EGFR-IN-64 (Compound 3c) is a highly potent inhibitor of the epidermal growth factor receptor (EGFR) with an IC 50 value of 0.33 μM. This compound, EGFR-IN-64, exhibits significant anticancer activity [1].
T60729	EGFR-IN-67
	EGFR-IN-67 (Compound 7d) is a potent inhibitor of EGFR with anticancer activity (IC 50 = 0.34 μM) [1].
T73154	EGFR-IN-70
	EGFR-IN-70 is a potent EGFR inhibitor with IC 50 values of 23.6 and 307.5 nM for EGFR LR/TM/CS and EGFR WT , respectively. EGFR-IN-70 has anti-proliferative activity and suppresses phosphorylation of the EGFR . EGFR-IN-...
T40785	Gefitinib impurity 1
	Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM). This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 5...
T1181L	Gefitinib hydrochloride
	Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent and orally active EGFR tyrosine kinase inhibitor (EGFR-TKI) (IC 50 = 33 nM) that selectively inhibits EGF-stimulated tumor cell growth (IC 50 = 54 nM) and that b...
T72431	Theliatinib tartrate	Xiliertinib tartrate,HMPL-309 tartrate,Xiliertinib tartrate ; HMPL-309 tartrate
	Theliatinib (Xiliertinib) tartrate is a potent and highly selective EGFR inhibitor, displaying ATP-competitive and orally active properties. It exhibits promising efficacy with a K_i of 0.05 nM and an IC_50 of 3 nM for E...
T72788	EGFR/C797S-IN-1
	EGFR/C797S-IN-1 is a potent inhibitor targeting the EGFR-C797S mutation, demonstrated by its IC 50 value of 0.128 µM. This compound exhibits significant anti-proliferative and anti-tumor effects by inhibiting p-EGFR expr...
T41155	MS 154
	MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib(Iressa). MS 154 decreases EG...
T83691	EGFR Peptide (human, mouse) TFA	Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH,Epidermal Growth Factor Receptor Peptide
	EGFR peptide, a PKC peptide substrate, mirrors an amino acid sequence from EGFR's intracellular region and serves to gauge PKC activity in primary bovine retinal endothelial cells. At a concentration of 50 µM, unlike its...
T35147	WZ4002-hydroxy	WZ4002 analog, WZ4002 demethyl derivate,WZ 4002-hydroxy,WZ-4002-hydroxy
	WZ4002-hydroxyl is a WZ4002 derivative or WZ4002 analogue in which methoxy is replaced by hydroxyl and can be detected in 50% of patients with clinical resistance to gefitinib or erlotinib. WZ4002 has a basic chemical sk...
T36251	DP-C-4		PROTACs
	DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP[1]. DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1]. [...		PROTACs
TN3525	Boehmenan		ERK , Phosphatase , EGFR , PARP , MEK , Wnt/beta-catenin , Akt , Caspase , STAT , p53
	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotox...
T36193	CAY10717
	CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM. It has activity at multiple oncogenic kinases, with IC50 va...
T35423	7-oxo Staurosporine
	7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respe...
T35897	ASK120067
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]...