Search Result

Search Results for " crf "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP2048L	α-helical CRF 9-41 acetate	α-helical CRF 9-41 acetate(90880-23-2 Free base)	CRFR
	α-helical CRF 9-41 acetate is a competitive antagonist of CRF2 (KB = 100 nM) and a partial agonist of CRF1 (EC50 = 140 nM).		CRFR
TP2047L	CRF (6-33) acetate(120066-38-8 free base)		CRFR
	CRF (6-33) acetate is a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.		CRFR
TP2047	CRF(6-33)(human)	CRF (6-33)
	CRF(6-33)(human) is a Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.
TP2048	α-Helical CRF(9-41)	α-helical CRF 9-41
	Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).
TP1191	CRF, bovine	Corticotropin Releasing Factor bovine
	CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
TP1190	CRF, bovine TFA (92307-52-3 free base)	CRF, bovine TFA,Corticotropin Releasing Factor bovine TFA
	CRF, bovine (TFA) is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM[1]. CR...
T75972	CRF, bovine TFA
	CRF, bovine (TFA), acts as a potent agonist for the CRF receptor and effectively displaces [125I-Tyr]ovine CRF, demonstrating a K_i of 3.52 nM [1].
T83665	α-Helical CRF (9-41) TFA	α-Helical Corticotropin-Releasing Factor (9-41)
	α-Helical CRF (9-41) is a synthetic peptide antagonist that targets corticotropin-releasing factor (CRF), effectively inhibiting CRF-induced adrenocorticotropic hormone (ACTH) release both in vitro, with isolated rat ant...
T75893	CRF(6-33)(human) TFA
	CRF(6-33)(human) TFA acts as a competitive inhibitor of the Corticotropin-Releasing Factor Binding Protein (CRF-BP), selectively interacting with CRF-BP without affecting post-synaptic Corticotropin-Releasing Factor rece...
T75891	α-Helical CRF(9-41) TFA
	α-Helical CRF(9-41) TFA acts as a competitive antagonist for the CRF2 receptor, possessing a binding constant (K B) of approximately 100 nM. Additionally, it serves as a partial agonist for the CRF1 receptor, exhibiting ...
TP1144	Corticotropin-releasing factor (human)	Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human
	Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous syst...
T76602	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)
	(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a corticotropin-releasing factor (CRF) antagonist known to counteract the inhibitory effects of IL-1a on Luteinizing hormone (LH) production [1].
T12276	NVS-CRF38		Others
	NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1).		Others
T79793	CRF1 receptor antagonist-1		CFTR
	CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].		CFTR
T69871	ICRF-196
	ICRF-196 is a Topoisomerase II Inhibitor and antineoplastic agent.
T71177	LCRF-0004
	LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority o...
T69870	ICRF-193
	ICRF-193 is a DNA topoisomerase II inhibitor.
T25893	NU/ICRF 500
	NU/ICRF 500 is a novel anthracenyl-amino acid catalytic inhibitor of topoisomerase II.
T60126	4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine		Others , CRFR
	4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric counterpart of SSR-125543. SSR-125543 is a potent CRF-R1 antagoni...		Others , CRFR
TP1448L	Astressin acetate	Astressin acetate (170809-51-5 Free base)	CRFR
	Astressin acetate is an antagonist of corticotropin releasing factor (CRF) with low affinity for the CRF binding protein and high affinity for the cloned pituitary receptor(Ki = 2 nM).		CRFR
TP2221L	ANP (1-11), rat acetate	Atrial natriuretic factor (1-11) acetate,Atriopeptide (1-11) acetate	Others
	ANP (1-11), rat acetate (Atrial natriuretic factor (1-11) acetate) is one of the atrial natriuretic factors, inhibitors of CRF-stimulated ACTH secretion.		Others
TP1199L	Urotensin I acetate (83930-33-0 Free base)		CRFR
	Urotensin I acetate, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hC...		CRFR
T7361	Verucerfont	NBI77860,GSK561679	CRFR
	Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .		CRFR
T16713	R121919	NBI30775	Others
	R121919 (NBI30775) is a potent small molecule adrenocorticotropic hormone-releasing factor receptor 1 (CRF1) receptor antagonist with antidepressant and anxiolytic activity that inhibits the CRF1 receptor, the CRF2 recep...		Others
T12492	Pivagabine	CXB-722	GABA Receptor
	Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor...		GABA Receptor
TP1504	Urocortin III, mouse TFA (357952-10-4 free base)	Urocortin III, mouse TFA
	Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response sys...
T76180	Urocortin III (human)
	Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide that primarily interacts with and activates the CRF receptor type 2 (CRF-R2), showing a specific distribution in the central nervous system ...
T25864	NGD9002	NGD-9002,NGD 9002
	NGD9002 is a novel generation, topology 2 selective corticotropin releasing factor-1 (CRF-1) receptor antagonist agent.
T76492	(Tyr0)-Urocortin, rat
	(Tyr0)-Urocortin, rat, serves as a high-affinity agonist for both corticotropin-releasing factor receptor type 1 (CRF-R1) and type 2 (CRF-R2), demonstrating inhibitory binding constants (Ki) of 1-2 nM [1].
T31052	CP-376395 HCl	CP-376395,UNII-5113G7FP34,CP376395
	CP 376395 hydrochloride is a potent and selective CRF-RI receptor antagonist.
T33607	NBI-34041	NBI34041,SB 723620,SB-723620,SB723620
	NBI-34041 is an effective and high-affinity CRF1 receptor antagonist that effectively reduces endocrine responses to CRF(1) receptor-mediated pharmacological and behavioral challenges.
T27057	CP 154,526	CP-154,526,CP154,526
	CP 154,526 is a selective CRF1 receptor antagonist (Ki = 2.7 nM). CP 154,526 blocks CRF-induced activation of adenylate cyclase and the HPA axis.
T27666	JNJ-19567470	JNJ19567470
	JNJ-19567470 is a selective, non-peptide CRF receptor 1 antagonist.
T76025	Urocortin III, mouse TFA
	Urocortin III, mouse TFA, a corticotropin-releasing factor (CRF)-related peptide, preferentially activates CRF-R2 [1], demonstrating its significant role in the behavioral stress response system as a component of Urocort...
T76204	A-Helical Corticotropin Releasing Factor (9-41)
	α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist that lowers plasma growth hormone (GH) levels in vivo [1] [2].
TP1020	Urocortin, rat	Urocortin (Rattus norvegicus),Rat urocortin
	Endogenous CRF agonist. Ki values are 13, 1.5 and 0.97 nM for hCRF1, rCRF2α and mCRF2β respectively.
T70433	Antalarmin
	Antalarmin is a CRF-1 antagonist. By blocking CRF-1 activity the release of ACTH is reduced, and chronic stress is decreased in response to chronic stress. Antalarmin could be useful in reducing the adverse health conseq...
T37111	Corticotropin-releasing factor (human) (acetate)
	Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
T69374	NGD 98-2
	NGD 98-2 is a new generation, topology 2 selective orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II...
TP1860	Urocortin II, human
	Human urocortin (hUcn) II is a new member of the corticotropin-releasing-factor (CRF) family. It selectively binds to the CRF2 receptor.
T35374L	(Ala13)-Apelin-13 acetate		Apelin receptor
	(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.		Apelin receptor
T75976	Urotensin I TFA
	Urotensin I (Catostomus urotensin I) TFA is a CRF-like neuropeptide that functions as an agonist for CRF receptors, demonstrating efficacy through pEC50 values of 11.46 for human CRF1, 9.36 for human CRF2, and 9.85 for r...
T75804	K41498 TFA
	K41498 TFA, an analog of antisauvagine-30 (aSvg-30), is a potent and highly selective antagonist of CRF2 receptors, exhibiting K i values of 0.66 nM, 0.62 nM, and 425 nM for human CRF 2α, CRF 2β, and CRF 1 receptors, res...
T62444	NBI-27914
	NBI-27914 is a potent and selective CRFR1 antagonist. The CRF receptors CRFR1 and CRFR2 are members of the G protein-coupled receptor superfamily.
T76510	[Asu1,6-Arg8]Vasopressin
	[Asu1,6-Arg8]Vasopressin is a vasopressin agonist that enhances cyclic AMP accumulation and adrenocorticotropic hormone (ACTH) release triggered by corticotropin-releasing factor (CRF) in cultured rat anterior pituitary ...
T35814	Urocortin III (human) (trifluoroacetate salt)
	Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin II...
TP2121	Sauvagine
	Corticotropin-releasing factor (CRF) receptor agonist. Ki values are 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b respectively.
TP1448	Astressin
	Astressin is an amino-terminal truncated analog of CRF that retains high affinity binding to the extracellular domain of the receptor and is believed to act as a neutral competitive antagonist of receptor activation.
T75894	Sauvagine TFA
	Sauvagine TFA, a mammalian CRF agonist derived from a 40-amino-acid neuropeptide found in frog skin, effectively releases ACTH from rat pituitary cells. It exhibits pharmacological effects on diuresis, the cardiovascular...

Compounds

α-helical CRF 9-41 acetate

TP2048L

Synonym: α-helical CRF 9-41 acetate(90880-23-2 Free base)

Target: CRFR

CRF (6-33) acetate(120066-38-8 free base)

Synonym: CRF (6-33)

Target:

α-Helical CRF(9-41)

TP2048

Synonym: α-helical CRF 9-41

Target:

CRF, bovine

TP1191

Synonym: Corticotropin Releasing Factor bovine

Target:

CRF, bovine TFA (92307-52-3 free base)

TP1190

Synonym: CRF, bovine TFA,Corticotropin Releasing Factor bovine TFA

α-Helical CRF (9-41) TFA

T83665

Synonym: α-Helical Corticotropin-Releasing Factor (9-41)

Target:

CRF(6-33)(human) TFA

T75893

Synonym:

Target:

α-Helical CRF(9-41) TFA

T75891

Synonym:

Target:

Corticotropin-releasing factor (human)

TP1144

Synonym: Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human

Target:

(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat)

CRF1 receptor antagonist-1

4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine

T60126

Synonym:

Target: Others, CRFR

Astressin acetate

TP1448L

Synonym: Astressin acetate (170809-51-5 Free base)

Target: CRFR

ANP (1-11), rat acetate

TP2221L

Synonym: Atrial natriuretic factor (1-11) acetate,Atriopeptide (1-11) acetate

Target: Others

Urotensin I acetate (83930-33-0 Free base)

Synonym: NBI77860,GSK561679

Target: GABA Receptor

Urocortin III, mouse TFA (357952-10-4 free base)

TP1504

Synonym: Urocortin III, mouse TFA

Target:

Urocortin III (human)

Synonym: NGD-9002,NGD 9002

Target:

(Tyr0)-Urocortin, rat

Synonym: CP-376395,UNII-5113G7FP34,CP376395

Target:

NBI-34041

T33607

Synonym: NBI34041,SB 723620,SB-723620,SB723620

Target:

CP 154,526

T27057

Synonym: CP-154,526,CP154,526

Urocortin III, mouse TFA

T76025

Synonym:

Target:

a-Helical Corticotropin Releasing Factor (9-41)

Synonym: Urocortin (Rattus norvegicus),Rat urocortin

Corticotropin-releasing factor (human) (acetate)

Urocortin II (mouse) (trifluoroacetate salt)

(Ala13)-Apelin-13 acetate

T35374L

Synonym:

Target: Apelin receptor

[Asu1,6-Arg8]Vasopressin

T76510

Synonym:

Target:

Urocortin III (human) (trifluoroacetate salt)

Cat No.	Product Name	Synonyms	Targets
T8150	Nudifloramide	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide	PARP , Endogenous Metabolite
	Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).		PARP , Endogenous Metabolite

Natural Products

Nudifloramide

T8150

Synonym: 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide

Target: PARP, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00906	CRHBP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. The molecule is approximately 300 amino acids in length and de...
TMPH-02608	Corticoliberin Protein, Mouse, Recombinant (His & KSI)	Mouse	E. coli
	Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.
TMPY-03412	GGCT Protein, Human, Recombinant (His)	Human	E. coli
	GGCT belongs to the gamma-glutamylcyclotransferase family. It catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism. GGCT may play a significant role in ...
TMPH-02555	C1QL1 Protein, Mouse, Recombinant (His)	Mouse	P. pastoris (Yeast)
	May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.
TMPY-02882	HIV-1 (group M, subtype CRF07_BC) gp140 Protein (His)	HIV	HEK293 Cells
	HIV-1 (group M, subtype CRF07_BC) gp140 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.2 kDa.
TMPY-01373	HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His)	HIV	HEK293 Cells
	HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.8 kDa and the accession number is I6TSC9.
TMPH-00550	Epstein-Barr virus (strain B95-8) BCRF1 Protein (His & Myc)	EBV	E. coli
	Plays a role in masking infected cells for immune recognition by cytotoxic T-lymphocytes. Down-regulates the expression of the host TAP1 gene (transporter associated with antigen processing), thereby affecting the transp...
TMPY-04061	HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP)	HIV	E. coli
	HIV-2 (subtype CRF01_AB, strain 07JP_NMC716_clone_01) gp36 Protein (His & MBP) is expressed in E. coli expression system with His and MBP tag. The predicted molecular weight is 58.8 kDa and the accession number is L8B302...
TMPY-01408	HIV-1 (group M, subtype CRF07_BC) gp140 Protein (hFc)	HIV	HEK293 Cells
	HIV-1 (group M, subtype CRF07_BC) gp140 Protein (hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 98 kDa.
TMPY-06486	HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His), Biotinylated	HIV	HEK293 Cells
	HIV-1 (group M, subtype CRF07_BC) gp120 Protein (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.8 kDa and the accession number is AFM77980.1.
TMPK-00474	IL-22RA1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component o...