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Pivagabine

Catalog No. T12492   CAS 69542-93-4
Synonyms: CXB-722

Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain.

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Pivagabine Chemical Structure
Pivagabine, CAS 69542-93-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
2 mg In stock $ 40.00
5 mg In stock $ 64.00
10 mg In stock $ 106.00
25 mg In stock $ 176.00
50 mg In stock $ 262.00
100 mg In stock $ 389.00
500 mg In stock $ 882.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor function and corticotropin-releasing factor (CRF) levels in the rat brain.
In vivo Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions[2].
Animal Research Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions, reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex[2].
Synonyms CXB-722
Molecular Weight 187.24
Formula C9H17NO3
CAS No. 69542-93-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49 mg/mL (261.69 mM)

TargetMolReferences and Literature

1. Esposito G, et al. Pivagabine: a novel psychoactive drug. Arzneimittelforschung. 1997 Nov;47(11A):1306-9. 2. Serra M, et al. Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain. Psychoneuroendocrinology. 1999 Apr;24(3):269-84.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Clinical Compound Library Bioactive Compounds Library Max ReFRAME Related Library Bioactive Compound Library Human Metabolite Library

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Keywords

Pivagabine 69542-93-4 Membrane transporter/Ion channel Neuroscience GABA Receptor blood-brain γ-Aminobutyric acid Receptor psychoactive derivative Inhibitor inhibit foot factor barrier CXB722 CXB-722 shock Gamma-aminobutyric acid Receptor CXB 722 neuromodulatory corticotropin-releasing inhibitor

 

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