cdk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64373	CDK1-IN-2	cdk1 inhibitor 2	CDK
	CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.		CDK
T14914	Cdk1/2 Inhibitor III		CDK
	Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.		CDK
T63080	CDK1-IN-4
	CDK1-IN-4 (10d) is a selective CDK1 inhibitor that acts on CDK1 (IC50: 44.52 nM), CDK2 (IC50: 624.93 nM) and CDK5 (IC50: 135.22 nM). CDK1-IN-4 affects the cell cycle and thus exhibits inhibitory effects on the growth of ...
T63437	CDK1-IN-5
	CDK1-IN-5 (10h) is a selective CDK1 inhibitor that acts on CDK1 (IC50: 42.19 nM), CDK2 (IC50: 188.71 nM) and CDK5 (IC50: 354.15 nM). CDK1-IN-5 affects the cell cycle and inhibits cancer cell growth and can be used in can...
T63933	CDK1-IN-3
	CDK1-IN-3 (8g) is a selective CDK1 inhibitor that acts on CDK1 (IC50: 36.8 nM), CDK2 (IC50: 305.17 nM) and CDK5 (IC50: 369.37 nM). CDK1-IN-3 can affect the cell cycle and thus inhibit the growth of cancer cells and can b...
T62970	CDK1-IN-1
	CDK1-IN-7 is a potent inhibitor of CDK1 with an IC50 value of 161.2 nM for CDK1/CycB. CDK1-IN-7 induces apoptosis in a p53-dependent manner via the apoptosis-intrinsic pathway. CDK1-IN-7 selectively acts on tumour tissue...
T62405	KDM1/CDK1-IN-1
	KDM1/CDK1-IN-1 (compound 4) is a potent inhibitor of KDM1 (IC50: 0.096 μM) and CDK1 (IC50: 0.078 μM). kDM1/CDK1-IN-1 blocks the cell cycle of HOP-92 cells in G2/M phase and induces apoptosis. KDM1/CDK1-IN-1 is highly cyt...
T61254	CDK1/Cyc B-IN-1
	CDK1/Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1/Cyc B complex, demonstrating selectivity with an IC50 value of 97 nM. This compound induces apoptosis and G2/M cell cycle arrest, effectively halting cancer ...
T60583	CDK1/2/4-IN-1
	CDK1/2/4-IN-1 (compound 3a) is a potent inhibitor of CDK with IC 50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 can be used in cancer research. CDK1/2/4-IN-1 arrests cell cycle a...
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
T7426	ALSTERPAULLONE		Apoptosis , GSK-3 , CDK
	Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec		Apoptosis , GSK-3 , CDK
T39752	CDK12-IN-2	CDK12 inhibitor 2,CDK12-IN-2	CDK
	CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CD...		CDK
T40289	CDK12-IN-6	CDK12-IN-6
	CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM). Notably, CDK12-IN-6 does not e...
T14990	CDK12-IN-3		CDK
	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).		CDK
T40288	CDK12-IN-4	CDK12-IN-4
	CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 μM, utilizing high ATP levels (2 mM). Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 μM) or C...
T14915	CDK12-IN-E9		CDK
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).		CDK
T64284	PROTAC CDK12/13 Degrader-1
	PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM). Breast cancer.
T40290	CDK12-IN-5	CDK12-IN-5
	CDK12-IN-5 is a pyrazolotriazine compound that effectively inhibits CDK12, with an IC50 value of 23.9 nM at a high ATP concentration of 2 mM. However, CDK12-IN-5 does not exhibit inhibitory effects on CDK2/Cyclin E (IC50...
T2356	Ro-3306		Apoptosis , ERK , SGK , PKA , CDK , PKC
	RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases.		Apoptosis , ERK , SGK , PKA , CDK , PKC
T2679	BMS-265246	BMS265246	CDK
	BMS-265246 is a potent and selective CDK1/2 inhibitor.		CDK