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CDK12-IN-3

Catalog No. T14990 CAS 2220184-50-7

CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).

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CDK12-IN-3, CAS 2220184-50-7

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1 mg	5 days	$ 148.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).
Targets&IC50	CDK12:491 nM
In vitro	CDK12-IN-3 is a selective CDK12 inhibitor that is profiled across a panel of 352 kinases at 0.1 μM. CDK12-IN-3 shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II. It also shows growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.

Molecular Weight	470.52
Formula	C23H28F2N8O
CAS No.	2220184-50-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Johannes JW, et al. Structure-Based Design of Selective Noncovalent CDK12 Inhibitors. ChemMedChem. 2018 Feb 6;13(3):231-235.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CDK12-IN-3 2220184-50-7 Cell Cycle/Checkpoint CDK CDK12IN3 CDK12 IN 3 CDK-12-IN-3 inhibitor inhibit

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