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Search Results for " akt/gsk3β "

8

Compounds

Cat No. Product Name Synonyms Targets
T2423 P7C3-A20 Others
P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.
T39341 FCPR03 PDE
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...
T2P2810 Methyl Linoleate Linoleic acid methyl ester,Telfairic Acid methyl ester Antioxidant
Methyl Linoleate (Telfairic Acid methyl ester) linoleate has antioxidant activity.
T14034 3CAI Akt
3CAI is a potent and specific AKT1 and AKT2 inhibitor which showed significant inhibition of AKT in an in vitro kinase assay and suppressed expression of AKT direct downstream targets such as mTOR and GSK as well as in...
T1830 BX795 IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than...
TN2091 Polygalacin D Apoptosis , IAP
Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxi...
TN6469 Biatractylolide
Biatractylolide has a neuroprotective effect on glutamate-induced injury in PC12 and SH-SY5Y cells through a mechanism of the PI3K-Akt-GSK-dependent pathways. The molecular mechanisms of inhibitory activities of biatra...
T61756 APN/AKT-IN-1
APN/AKT-IN-1 is a potent dual inhibitor of aminopeptidase N (APN) and protein kinase B (AKT), exhibiting IC50 values of 0.21 μM and 0.27 μM for APN and AKT inhibition, respectively. This compound effectively suppresses t...
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