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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13176 | TNO155 | Batoprotafib | Phosphatase |
TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity. | |||
T9756 | AZD-9574 | PARP | |
AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies. | |||
T16781 | Rogaratinib | BAY1163877 | FGFR |
Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR). Rogaratinib is as an orally available, selective and potent inhibitor of FGFR-1, -2 and -3 kinase activity. | |||
T62902 | NDI-034858 | TAK-279,NDI-03485 | IL Receptor , Tyrosine Kinases |
NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23. | |||
T79492 | H-NTPDase8-IN-1 | Phosphatase | |
h-NTPDase8-IN-1 is a specific aminosulfonylbenzamide inhibitor of h-NTPDases8 (IC 50 = 0.28 ± 0.07 μM). h-NTPDase8-IN-1 can be used to study diseases brought about by aberrant h -NTPDase expression. | |||
T5699 | SSE15206 | Apoptosis , Microtubule Associated | |
SSE15206 is a microtubule polymerization inhibitor that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells. | |||
T15576 | Indibulin | ZIO 301,D 24851 | Apoptosis , Microtubule Associated |
Indibulin (D 24851) is a synthetic small molecule with antimitotic and potential antineoplastic activities.Indibulin an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neu... | |||
TQ0236 | Tirabrutinib | ONO-4059,GS-4059,Velexbru | BTK |
Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and ... | |||
T3011 | 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid | Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine | Others , Endogenous Metabolite |
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) is a ketone and an amino acid derivative with diverse biological functions, including vasodilatory, immunoregulatory and neuromodulatory activities. 2-... | |||
T24647 | PKR-IN-C51 | PKRINC51,PKR IN C51,PKR-inhibitor-C51,PKR inhibitor C51 | |
PKR-IN-C51 is an inhibitor of protein kinase R. It acts by correcting the aberrant splicing of MBNL1-dependent pre-mRNAs in DM1 cells without affecting the splicing pattern in normal non-DM1 cells. | |||
T71639 | AUH-6-96 | ||
AUH-6-96 is an inhibitor of JAK/STAT signaling, inhibiting both constitutive and interleukin-6-induced STAT3 phosphorylation, selectively affecting cell viability only of cancer cells harboring aberrant JAK/STAT signalin... | |||
T70318 | AMG-337 monohydrate | ||
AMG-337 monohydrate is a highly selective small molecule MET inhibitor. Aberrant hepatocyte growth factor (HGF)/MET signaling has been implicated in hepatocarcinogenesis, suggesting that MET may serve as an attractive th... | |||
T61435 | (S)-Cdc7-IN-18 | ||
(S)-Cdc7-IN-18, a potent CDC7 inhibitor, effectively impedes the overactivation of MCM2, a crucial tumor cell marker, induced by huCdc7 overexpression. Consequently, it inhibits the aberrant proliferation of tumor cells.... | |||
T36718 | Tie2 Inhibitor 7 | ||
Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound c... | |||
T79672 | DUB-IN-7 | ||
DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1]. | |||
T70941 | CLR01 sodium | ||
CLR01 is a molecular tweezer. CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy. CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro ... | |||
T68267 | RO5068760 | ||
RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen... | |||
T60360 | LSD1/2-IN-3 | ||
LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 ( LSD1 ) with a Ki value of 11 nM rather than 7 μM for LSD2. There is aberrant expression of LSD1 in tumor stem cells, LSD1/2-IN-1 inhibits LSD1 cell ... | |||
T62680 | (R)-MLT-985 | ||
(R)-MLT-985 (compound 11) is a potent inhibitor of MALT1 protease (IC50: 3 nM). (R)-MLT-985 has an IC50 value of 20 nM for MALT1-dependent IL-2 in Jurkat cells.(R)-MLT-985 inhibits growth and aberrant CARD11/BCL10/MALT1 ... | |||
T70527 | DAT-230 | ||
DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -tr... |