ak3 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10009	JAK3-IN-7		JAK
	JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ...		JAK
T26585	AK301	AK-301,AK 301	Apoptosis , Microtubule Associated
	AK301 is a potent and selective inhibitor of tubulin polymerization and an effective sensitizer of cancer cells to apoptotic ligands (EC50 < 200 nM). Colon cancer cells arrested in mitosis with AK301 readily underwent a ...		Apoptosis , Microtubule Associated
T27650	JAK3i	JAK-3i,JAK 3i	JAK
	JAK3i is a selective covalent inhibitor of JAK3 kinase. JAK3i reveals two distinct temporal waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cel...		JAK
T26174	SAK3	SAK 3,SAK-3	Calcium Channel , AChR
	SAK3 is a novel modulator of nAChR activity that enhances T-type voltage-gated Ca2+ channel (T-VGCC) activity, and has potentiating effects on both Cav3.1 and Cav3.3 T-type Ca2+ channel currents.SAK3 is neuroprotective a...		Calcium Channel , AChR
T67754	JAK3-IN-14		FLT
	JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.		FLT
T5492	JAK3-IN-6		JAK
	JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM		JAK
T62553	JAK3/BTK-IN-4
	JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signaling pathway has a synergistic effect and JAK3/BTK-IN-4 has pot...
T61814	JAK3-IN-9
	JAK3-IN-9 is a potent and orally active inhibitor of the Janus kinase 3 (JAK3) enzyme, displaying an impressive IC50 value of 1.7 nM. It exhibits high selectivity towards the JAK3 signaling pathway, making it a valuable ...
T62234	JAK3/BTK-IN-3
	JAK3/BTK-IN-3 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-3 has sh...
T62114	JAK3-IN-12
	JAK3-IN-12 (compound 15k) is a potent inhibitor of JAK3 (IC50: 9.5 nM) and can be used in the study of rheumatoid arthritis.
T15607	JAK3-IN-1		Others
	JAK3-IN-1 is a selective and orally active JAK3 inhibitor (IC50: 4.8 nM). JAK3-IN-1 displays over 180-fold more selective for JAK3 than JAK1 (IC50: 896 nM) and JAK2 (IC50: 1050 nM).		Others
T62153	JAK3/BTK-IN-5
	JAK3/BTK-IN-5 is a potent inhibitor of JAK3/BTK. where BTK and JAK3 are two key targets in autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway has a synergistic effect and JAK3/BTK-IN-5 has po...
T63749	JAK3-IN-13
	JAK3-IN-13 is a potent, selective, orally active JAK3 inhibitor that acts on NK1 (IC50: 4728 nM), JNK2 (IC50: 2039 nM), JNK3 (IC50: 8 nM), and Tyk2 (IC50: 365 nM). JAK3-IN-13 exhibits anti-tumor effects.
T11709	JAK3 covalent inhibitor-1		JAK
	JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and demonstrating a 246-fold selectivity compared to other JAKs.		JAK
T40334	PROTAC IRAK3 degrade-1	PROTAC IRAK3 degrade-1
	PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
T9814	JAK3/BTK-IN-1		JAK , BTK
	JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important targets in autoimmune diseases. JAK3/ BTk-in-1 simultaneously inh...		JAK , BTK
T9813	JAK3/BTK-IN-2		JAK , BTK
	JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor. JAK3/ BTk-in-2 inhibits both BTK and JAK3, which are two important targets IN autoimmune diseases. JAK3/ BTk-in-2 simultaneously inhibits the BTK/JAK3 signaling pathway, sho...		JAK , BTK
T77931	PROTAC IRAK3 degrade-1 formic		PROTACs
	PROTAC IRAK3 Degrade-1 (Compound 23) is a selective and potent IRAK3 degrader, demonstrating an IC50 value of 5 nM [1].		PROTACs
T62813	JAK3/BTK-IN-6
	JAK3/BTK-IN-6 is a potent dual inhibitor of BTK (IC50: 0.6 nM) and JAK3 (IC50: 0.4 nM).JAK3/BTK-IN-6 exhibits good metabolic stability in human liver microsomes.JAK3/BTK-IN-6 can be used to study blood and immune disease...
T9811	JAK3-IN-11
	JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently bi...
T62556	JAK-IN-23
	JAK-IN-23 is an orally active dual JAK/STAT and NF-κB inhibitor that inhibits J AK1 (IC50: 8.9 nM), J AK2 (IC50: 15 nM), and J AK3 (IC50: 46.2 nM). JAK-IN-23 exhibits strong anti-inflammatory effects and can reduce the r...

Compounds

JAK3-IN-7

T10009

Synonym: AK-301,AK 301

Target: Apoptosis, Microtubule Associated

JAK3i

T27650

Synonym: JAK-3i,JAK 3i

Target: Calcium Channel, AChR

JAK3 covalent inhibitor-1

T11709

Synonym:

Target: JAK

PROTAC IRAK3 degrade-1

T40334

Synonym: PROTAC IRAK3 degrade-1

PROTAC IRAK3 degrade-1 formic

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01417	AK3 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	AK3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-04469	AK3L1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	AK3L1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 53 kDa and the accession number is P27144-1.
TMPY-04755	AK3L1 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	AK3L1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 25.3 kDa and the accession number is P27144-1.
TMPH-02739	IRAK3 Protein, Mouse, Recombinant (E. coli, His & Myc)	Mouse	E. coli
	IRAK3 Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli.
TMPH-02738	IRAK3 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by ...