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SAK3

Catalog No. T26174 CAS 1256269-87-0

Synonyms: SAK 3, SAK-3

SAK3 is a novel modulator of nAChR activity that enhances T-type voltage-gated Ca2+ channel (T-VGCC) activity, and has potentiating effects on both Cav3.1 and Cav3.3 T-type Ca2+ channel currents.SAK3 is neuroprotective against scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells.SAK3 is used for the study of memory deficits and Alzheimer's disease. SAK3 can be used to study memory deficits and Alzheimer's disease.

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SAK3, CAS 1256269-87-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 129.00
5 mg	In stock	$ 325.00
10 mg	In stock	$ 483.00
25 mg	In stock	$ 778.00
50 mg	In stock	$ 1,060.00
100 mg	In stock	$ 1,430.00

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Purity: 99.55%

Purity: 98.70%

Biological Description

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Description	SAK3 is a novel modulator of nAChR activity that enhances T-type voltage-gated Ca2+ channel (T-VGCC) activity, and has potentiating effects on both Cav3.1 and Cav3.3 T-type Ca2+ channel currents.SAK3 is neuroprotective against scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells.SAK3 is used for the study of memory deficits and Alzheimer's disease. SAK3 can be used to study memory deficits and Alzheimer's disease.
In vitro	In Neuro2A cells overexpressing Cav3.1 or Cav3.3, SAK3 (0.1 nM; 270 s) rapidly increases Ca2+ currents[2].
In vivo	In Cav3.1 knockout (KO) mice animal model, SAK3 (0.5 mg/kg; administered p.o.) significantly increased acetylcholine (ACh) release in the CA1 region, peaking at 20 minutes after oral administration[1].

Synonyms	SAK 3, SAK-3
Molecular Weight	369.41
Formula	C20H23N3O4
CAS No.	1256269-87-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yasushi Yabuki, et al. Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology. 2017 May 1;117:1-13. 2. Jing Xu, et al.T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model. Int J Mol Sci. 2021 Jun 8;22(12):6185.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SAK3 1256269-87-0 Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel AChR SAK 3 SAK-3 inhibitor inhibit

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