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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7378 | BRD9539 | Histone Methyltransferase | |
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM | |||
T17204 | UNC0321 | Histone Methyltransferase | |
UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays. | |||
T17203 | UNC0224 | Histone Methyltransferase | |
UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM. | |||
T1923 | BRD4770 | Histone Methyltransferase | |
BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence. | |||
T4328 | OSS_128167 | SIRT6-IN-1 | HBV , Sirtuin |
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). | |||
T14991 | CMS-121 | CMS121 | Acetyl-CoA Carboxylase |
CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotect... | |||
T6593 | ML324 | Histone Demethylase , Others , HSV | |
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2). | |||
T77697 | BML-278 | BML278,BML 278 | Sirtuin , Histone Methyltransferase |
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind... | |||
T24793 | SIRT6-IN-5 | SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5 | Sirtuin |
SIRT6-IN-5(SIRT6 inhibitor 5) is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, ... | |||
T21715 | BRD6688 | HDAC | |
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes | |||
T38774 | E67-2 | E67-2 | |
E67-2, a derivative of E67, is a low-toxicity, selective inhibitor of the KIAA1718 Jumonji domain. It has an IC 50 value of 3.4 μM. E67-2 specifically inhibits the Jumonji demethylase for histone H3 lysine 9 (H3K9) and h... | |||
T69937 | INCB059872 tosylate | ||
INCB059872, also known as INCB59872, is a potent, selective, and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target gene... | |||
T39799 | S2157 | S2157 | |
S2157, a potent N-alkylated tranylcypromine (TCP) derivative lysine-specific demethylase 1 (LSD1) inhibitor, enhances H3K9 methylation and concurrently reduces H3K27 acetylation at super-enhancer sites. This compound tri... | |||
T79713 | JMJD3/HDAC-IN-1 | HDAC | |
Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone deacetylase, IC50 = 16 nM). It induces hypermethylation of his... | |||
T79714 | HDAC3-IN-2 | HDAC | |
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells. Demonstrating cytotoxic activity, HDAC3-IN-2 exhibits an IC50 of 0.55 ... | |||
T39800 | S2116 | ||
S2116 is a powerful inhibitor of lysine-specific demethylase 1 (LSD1), and it is a derivative of N-alkylated tranylcypromine (TCP). S2116 exhibits its inhibitory effects by increasing H3K9 methylation and inducing recipr... | |||
T64187 | HDAC1/6-IN-1 | ||
HDAC1/6-IN-1 is a potent multi-target inhibitor of GLP (IC50: 1.3 nM), HDAC6 (IC50: 13 nM) and HDAC1 (IC50: 89 nM). HDAC1/6-IN-1 inhibits the methylation and deacetylation of H3K9 at the protein level. HDAC1/6-IN-1 can b... | |||
T63935 | Bomedemstat hydrochloride | ||
Bomedemstat (IMG-7289) hydrochloride is an orally active, irreversible inhibitor of lysine-specific demethylase 1 (LSD1). Bomedemstat hydrochloride exhibits anticancer effects by inhibiting the proliferation of cancer ce... |