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TargetMol | Compound Library

Epigenetics Compound Library

Catalog No. L1200

Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear organization, DNA methylation, histone modification and RNA transcription. Epigenetic processes can result in intergenerational (heritable) effects as well as clonal propagation of cell identity without any mutational change in DNA sequence. Epigenetics has the potential to be a key element in a paradigm change of our understanding of aging, development, cancer, heart disease, psychological disorders, and other diseases. For example, Epigenetic modifications have a considerable effect on cancer. Changes in the pattern of histone modifications in the promoter sequences as epigenetic regulation lead to changes in chromatin structure thus may be the cause of altered gene expression by activation of oncogenes. The Epigenetics Compound Library by TargetMol, containing 1260 compounds related to epigenetic regulation, can be used for research in epigenetics, high throughput screening and high content screening for new drugs in epigenetic modification.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1200

Epigenetics Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • Quantity: well-chosen 1260 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs;
  • Targets include HDAC, SIRT, HAT, and HMT, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description, providing reference for your experimental design;
  • NMR and LCMS/HPLC validated to ensure high purity and quality.
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Advantages Introduction Advantages Introduction

High-Standard Entry Criteria

TargetMol’s Epigenetics Compound Library is curated with stringent entry criteria to ensure that every compound in the collection is structurally well-defined and of high purity. Multiple analytical techniques—such as NMR, HPLC, and LCMS—are employed to verify compound integrity. Through a multi-layered screening process, we exclude mixtures, polymers, and other compounds with undefined structures.

Significant Structural Diversity

TargetMol’s Epigenetics Compound Library features remarkable structural diversity, offering significant advantages in drug discovery. Based on an 85% MACCS fingerprint similarity analysis, the library can be divided into 1,052 clusters, covering a wide range of chemical space. The collection encompasses compounds of varying complexity, from simple to intricate chemical structures. This diversity greatly expands the potential for identifying lead compounds with high affinity and specificity toward target proteins, thereby driving drug innovation. Whether addressing traditional drug targets or emerging, more challenging ones, the Epigenetics Library provides a rich source of candidate compounds, accelerating the pace of drug development.

 Epigenetics Compound Library
Library Diversity Analysis

Superior Drug-likeness

71% compounds in this library comply with Lipinski’s “Rule of Five” (Ro5), indicating favorable bioavailability and permeability.

 Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library  Epigenetics Compound Library
Analysis on Drug-like Property

Multidimensional Pharmacokinetic Analysis

The Epigenetics Compound Library underwent multidimensional ADMET prediction and evaluation, with a systematic analysis of the following six key pharmacokinetic parameters: blood-brain barrier permeability, cardiac toxicity risk (HERG K+ channel inhibition), plasma protein binding affinity, oral absorption, intestinal absorption, and dermal absorption.

 Epigenetics Compound Library  Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library

Rich Variety of Compounds

Epigenetic modification refers to the regulation of gene expression without altering the DNA sequence, through mechanisms such as DNA methylation, histone modifications (e.g., methylation, acetylation, deacetylation), and non-coding RNA regulation. These processes play critical roles in pathological conditions including cancer, neurodegenerative diseases, and immune disorders. TargetMol’s Epigenetic Compound Library is a carefully curated collection of high-quality bioactive small molecules targeting key epigenetic regulators such as Epigenetic Reader Domains, Histone Methyltransferases, HDACs, Sirtuins, Histone Demethylases, Histone Acetyltransferases, DNA Methyltransferases, and MicroRNAs. This library provides comprehensive support for epigenetics research, target validation, and innovative drug discovery.

 Epigenetics Compound Library

TargetMol’s Epigenetics Compound Library includes 100+ approved drugs authorized by regulatory agencies such as FDA, EMA, PMDA, and NMPA, as well as 270+ clinical candidates currently in trials. In addition, it features 170+ natural compounds derived from plants, animals, and microorganisms, providing comprehensive support for research on epigenetics-related diseases.

 Epigenetics Compound Library

Regular Updates to Compound Libraries

TargetMol ensures compound libraries stay at the forefront of science by regularly updating our database to include the latest approved and marketed drugs.

Flexible Packaging Options

TargetMol provides a variety of standard packaging sizes (such as 30 μL, 50 μL, 100 μL, 250 μL, and 1 mg), and offer customized packaging solutions tailored to specific needs.

Personalized Custom Services

TargetMol offers fully customized screening services, including the design and synthesis of compound libraries. Our highly flexible service is designed to efficiently meet the unique needs of scientists and researchers.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
Epigenetic Reader Domain
Histone Methyltransferase
HDAC
JAK
Autophagy
PKC
PARP
AMPK
HIF/HIF Prolyl-Hydroxylase
Sirtuin
Histone Demethylase
Aurora Kinase
Endogenous Metabolite
HIF
Histone Acetyltransferase
CDK
Antibacterial
FLT
Tyrosine Kinases
Pim
DNA Methyltransferase
HIV Protease
NF-κB
STAT
Caspase
PKA
Parasite
Akt
VEGFR
Virus Protease
Reactive Oxygen Species
Wnt/beta-catenin
ERK
Mitophagy
PROTACs
Influenza Virus
Src
Bcl-2 Family
PI3K
MicroRNA
EGFR
Antibiotic
DNA/RNA Synthesis
p38 MAPK
COX
FGFR
ROCK
PDGFR
MDM-2/p53
Cytochromes P450
Bcr-Abl
PAD
GSK-3
Calcium Channel
c-RET
PPAR
Casein Kinase
TNF
Topoisomerase
Methionine Adenosyltransferase (MAT)
Antifungal
Syk
mTOR
Nrf2
Monoamine Oxidase
JNK
IL Receptor
Phosphatase
Serine/threonin kinase
Antiviral
MEK
Interleukin
AChR
Ligands for Target Protein for PROTAC
PLK
Potassium Channel
Ferroptosis
Adenosine Receptor
Dehydrogenase
CaMK
5-HT Receptor
S6 Kinase
Microtubule Associated
IκB/IKK
Nucleoside Antimetabolite/Analog
DYRK
c-Myc
GABA Receptor
PD-1/PD-L1
PDE
p53
NO Synthase
Anti-infection
c-Kit
Histamine Receptor
SARS-CoV
Gamma-secretase
MMP
Chk
MAPK
HSV
MAO
TLR
IDO
SGK
Fatty Acid Synthase
Indoleamine 2,3-Dioxygenase (IDO)
RAAS
Glucosidase
DNA Alkylation
TGF-beta/Smad
HSP
Serine Protease
Angiotensin-converting Enzyme (ACE)
DUB
Trk receptor
c-Fms
Antioxidant
HBV
NR4A
Cholinesterase (ChE)
IGF-1R
ATP Citrate Lyase
HER
Carboxypeptidase
Reverse Transcriptase
HCV Protease
LDL
BTK
Transferase
YAP
IFNAR
Telomerase
transporter
HuR
Beta Amyloid
Dopamine Receptor
Drug Metabolite
Antifection
Androgen Receptor
DAPK
Integrin
Cholecystokinin Receptor
Myosin
NMDAR
Mitochondrial Metabolism
Carbonic Anhydrase
E1/E2/E3 Enzyme
Hippo pathway
CFTR
c-Met/HGFR
NOD
Sodium Channel
OXPHOS
P-gp
Cannabinoid Receptor
Tyrosinase
MLK
ADC Cytotoxin
PGK1
BACE
NADPH
TRP/TRPV Channel
Adrenergic Receptor
Raf
GRK
Molecular Glues
SGLT
PSMA
BMI-1
NOD-like Receptor (NLR)
Estrogen/progestogen Receptor
Antifolate
RIP kinase
UGT
P2X Receptor
Thrombopoietin Receptor
Aminopeptidase
Proteasome
NPC1L1
DNA-PK
Reductase
Tie-2
Estrogen Receptor/ERR
SIK
Hedgehog/Smoothened
Beta-Secretase
Acyltransferase
Phospholipase
TAM Receptor
Liposome
Amino Acids and Derivatives
Glucokinase
Immunology/Inflammation related
PAFR
Glucagon Receptor
ROS
Ras
S1P Receptor
PERK
IAP
Monoamine Transporter
CCR
GluR
cGAS
Kras
Hydroxylase
Mdm2
gp120/CD4
PAK
Lipoxygenase
MELK
ROS Kinase
Chloride channel
Proton pump
NOS
MyD88
DNA Alkylator/Crosslinker
Aryl Hydrocarbon Receptor
DNA gyrase
Guanylate cyclase
CXCR
PTEN
Prostaglandin Receptor
LRRK2
Free radical scavengers
Pyroptosis
Retinoid Receptor
NADPH-oxidase