Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.Ro 90-7501 exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 68.00 | |
10 mg | In stock | $ 123.00 | |
25 mg | In stock | $ 272.00 | |
50 mg | In stock | $ 463.00 | |
100 mg | In stock | $ 787.00 |
Description | Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.Ro 90-7501 exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV. |
In vitro |
Compared to control HeLa and ME-180 cells, Ro 90-7501 significantly enhances radiation sensitivity. Following irradiation, Ro 90-7501 markedly increases apoptosis and impairs the cell cycle. Post-irradiation, Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2[2]. RO 90-7501 itself does not affect IFN-β and NFκB promoter activity but significantly enhances poly I:C-induced IFN-β promoter activation and dose-dependently inhibits NF-κB activation. Treatment with RO 90-7501 significantly enhances the antiviral activity of poly I:C[1]. |
In vivo | Treatment with Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; continuous for 21 days; female BALB/c nude mice) significantly delays tumor growth and markedly reduces tumor volume[2]. |
Synonyms | RO-90-7501 |
Molecular Weight | 340.38 |
Formula | C20H16N6 |
CAS No. | 293762-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (88.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Ro 90-7501 293762-45-5 Apoptosis DNA Damage/DNA Repair Metabolism Neuroscience PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells ATM/ATR Phosphatase Gamma-secretase RO-90-7501 Ro 907501 Ro 90 7501 inhibitor inhibit