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Prednisolone

Prednisolone
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Catalog No. T1560Cas No. 50-24-8
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Purity:99.85%
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Prednisolone

Catalog No. T1560Cas No. 50-24-8
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
Pack SizePriceAvailabilityQuantity
50 mg$29In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Prednisolone (Hydroretrocortine) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
In vitro
In guinea pigs, Prednisolone significantly reduces the partial pressure of oxygen in the pleural lining (PL-oxygen tension). In rats, Prednisolone (5 mg/kg) induces diaphragm contraction and histological alterations, resulting in an increased number of diaphragm bundles.
In vivo
In quadriceps and soleus muscles, Prednisolone (0.75 mg/kg) is effective in reducing the populations of macrophages, CD4(+) T cells, CD8+ T cells, and eosinophils. At a dosage of 50 mg/kg, Prednisolone suppresses the levels of mRNA for NOS stimulated by lipopolysaccharides in neutrophils of mice. Furthermore, Prednisolone mediates its anti-inflammatory effects by decreasing the expression of cell adhesion molecules.
AliasPredonine, Hydroretrocortine, Metacortandralone
Chemical Properties
Molecular Weight360.44
FormulaC21H28O5
Cas No.50-24-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 10 mg/mL (27.74 mM)
DMSO: 45 mg/mL (124.85 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.7744 mL13.8719 mL27.7439 mL138.7193 mL
5 mM0.5549 mL2.7744 mL5.5488 mL27.7439 mL
10 mM0.2774 mL1.3872 mL2.7744 mL13.8719 mL
20 mM0.1387 mL0.6936 mL1.3872 mL6.9360 mL
DMSO
1mg5mg10mg50mg
50 mM0.0555 mL0.2774 mL0.5549 mL2.7744 mL
100 mM0.0277 mL0.1387 mL0.2774 mL1.3872 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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