Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of the motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 46.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of the motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors. |
Targets&IC50 | dopamine D:588 nM (Ki), dopamine D2:1.4 nM (Ki), α1-adrenoceptor:39 nM (Ki), dopamineD3:2.5 nM (Ki) |
Synonyms | R6238 |
Molecular Weight | 461.55 |
Formula | C28H29F2N3O |
CAS No. | 2062-78-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (13 mM)
You can also refer to dose conversion for different animals. More
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Pimozide 2062-78-4 GPCR/G Protein JAK/STAT signaling Membrane transporter/Ion channel Neuroscience Stem Cells Potassium Channel Dopamine Receptor Adrenergic Receptor STAT Beta Receptor Inhibitor inhibit R6238 R-6238 R 6238 inhibitor