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NO-prednisolone

Catalog No. T19480 CAS 327610-87-7

Synonyms: NCX-1015

NO-prednisolone (NCX-1015) is a compound that effectively stimulates the production of IL-10 in vivo. It is a Prednisolone derivative that releases nitric oxide (NO).

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NO-prednisolone, CAS 327610-87-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 116.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 463.00
25 mg	In stock	$ 882.00
50 mg	In stock	$ 1,190.00
100 mg	In stock	$ 1,630.00
500 mg	In stock	$ 3,270.00
1 mL * 10 mM (in DMSO)	In stock	$ 318.00

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Purity: 99.31%

ee: 99.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NO-prednisolone (NCX-1015) is a compound that effectively stimulates the production of IL-10 in vivo. It is a Prednisolone derivative that releases nitric oxide (NO).
In vitro	'NO-prednisolone (NCX-1015) demonstrates superior effectiveness compared to Prednisolone in reducing inflammation, inhibiting the generation of cytokines and chemokines, and enhancing the expression of the steroid-sensitive cell-surface marker CD163 in human peripheral blood mononuclear cells.[1] Additionally, NO-prednisolone exhibits greater potency than Prednisolone in inducing CD163 cell surface expression. This heightened efficacy of NO-prednisolone, relative to the parent molecule Prednisolone, is also observed in the inhibition of IL-1β production induced by LPS (lipopolysaccharide).[2]'
In vivo	In vivo, NO-prednisolone (NCX-1015) potently stimulates IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation. The two doses of NO-prednisolone tested, 0.5 and 5 mg/kg/day effectively attenuate the severity of the wasting syndrome, ameliorate the colitis score, and reduce the colonic myeloperoxidase (MPO) activity. NO-prednisolone administration also reduces the colonic mRNA and protein content of tumor necrosis factor-α, IL-12, and IFN-γ. NO-prednisolone also reduces the expression of inducible NO synthase and cyclooxygenase-2. In a chronic model of granulomatous tissue inflammation, administration of NCX-1015 (13.9 μmol/kg）can effectively reduce the weight of dry granulomas, while exhibiting a lower anti-angiogenic effect.[1]

Synonyms	NCX-1015
Molecular Weight	539.57
Formula	C29H33NO9
CAS No.	327610-87-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (41.7 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Fiorucci S, et al. NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Proc Natl Acad Sci U S A. 2002;99(24):15770-15775. 2. Paul-Clark M, et al. 21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties. Br J Pharmacol. 2000;131(7):1345-1354.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

NO-prednisolone 327610-87-7 Immunology/Inflammation IL Receptor NCX1015 NCX 1015 NCX-1015 inhibitor inhibit

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