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Mivacurium dichloride

Catalog No. T22371 CAS 106861-44-3

Synonyms: Mivacurium chloride

Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.

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Mivacurium dichloride Chemical Structure

Mivacurium dichloride, CAS 106861-44-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 40.00
5 mg	In stock	$ 63.00
10 mg	In stock	$ 91.00
25 mg	In stock	$ 132.00
50 mg	In stock	$ 209.00
100 mg	In stock	$ 318.00
200 mg	In stock	$ 482.00
1 mL * 10 mM (in DMSO)	In stock	$ 97.00

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Purity: 99.52%

Purity: 99.2%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mivacurium dichloride (Mivacurium chloride) is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea.
In vitro	Mivacurium caused pseudo-allergic reactions in wild-type mice by inducing mast cells to release histamine.?However, it did not induce a similar phenomenon in KitW-sh/W-sh mice.?Furthermore, MrgprB2-knockout mice displayed no inflammatory response to mivacurium.?Mivacurium induced LAD2 cell degranulation in a dose-dependent manner.?Mivacurium stimulated intracellular calcium ion (Ca2+) influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells.?However, mivacurium induced the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering (si)RNA.?Notably, cytokine release was not observed in LAD2 cells even when stimulated with high concentrations of mivacurium[1].
In vivo	Mivacurium is rapidly hydrolyzed in the plasma with a short duration of action(< 10 min). Mivacurium has lots of advantages, like a rapid effect, nonneurological toxicity and a lack of heart rate alteration. Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature[1].

Synonyms	Mivacurium chloride
Molecular Weight	1100.17
Formula	C58H80Cl2N2O14
CAS No.	106861-44-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 100 mg/ml (90.9 mM)

DMSO: 100 mg/ml (90.9 mM)

H2O: 100 mg/ml (90.9 mM)

References and Literature

1. Delu Che, et al. Mivacurium Induce Mast Cell Activation and Pseudo-Allergic Reactions via MAS-related G Protein Coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128. 2. J E Caldwell. New Skeletal Muscle Relaxants. Int Anesthesiol Clin. Winter 1995;33(1):39-60.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Approved Drug Library Pediatric Drug Library Anti-Parkinson's Disease Compound Library FDA-Approved Drug Library Neurotransmitter Receptor Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Mivacurium dichloride 106861-44-3 Neuroscience AChR skeletal nAChR inhibit muscle Nicotinic acetylcholine receptors Inhibitor Mivacurium Dichloride Short-duration Mivacurium chloride non-depolarizing neuromuscular relaxant Mivacurium steroidal Mivacurium Chloride benzylisoquinoline inhibitor

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