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Irisolidone

Catalog No. TN1035 CAS 2345-17-7

Synonyms: 葛花苷元, 尼泊尔鸢尾异黄酮

Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.

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Irisolidone, CAS 2345-17-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Irisolidone is a potent volume-regulated anion channel (VRAC) current inhibitor, it exhibits high efficacy for VRAC blockade with IC50s of 5-13 μM.
In vivo	Irisolidone may attenuate ethanol-induced gastritis by inhibiting the infiltration of immune cells, particularly neutrophils, through the regulation of CXCL-4 or IL-8 secretion[2].

Synonyms	葛花苷元, 尼泊尔鸢尾异黄酮
Molecular Weight	314.29
Formula	C17H14O6
CAS No.	2345-17-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation.Pflugers Arch. 2018 Jun 30. 2. Geum-Dan, Kang, Sang-Yoon, et al. Irisolidone attenuates ethanol-induced gastric injury in mice by inhibiting the infiltration of neutrophils[J]. Molecular Nutrition & Food Research, 2016.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Ion Channel Inhibitor Library Immunology/Inflammation Compound Library NF-κB Signaling Compound Library Rare Natural Compound Library Anti-Aging Compound Library Bioactive Compound Library

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Related compounds with same targets

Triptoquinone A Tilifodiolide Nortrachelogenin Kaerophyllin Flavoglaucin Broussonin A 9-O-Feruloyl-5,5'-dimethoxylariciresinol 3,5-Dicaffeoyl-epi-quinic acid

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Irisolidone 2345-17-7 NF-Kb信号通路离子通道免疫与炎症 IL Receptor NF-κB Chloride channel Chloride Channel Cl? Channels Inhibitor hepatoprotective inhibit VRAC inhibitor

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