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GS-443902

Catalog No. T5539 CAS 1355149-45-9

Synonyms: 瑞德西韦代谢物

Remdesivir triphosphate is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp) with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GS-443902, CAS 1355149-45-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Remdesivir triphosphate is a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp) with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir.
Targets&IC50	RSV RdRp:1.1 µM (IC50), HCV RdRp:5 µM (IC50)
Animal Research	Cats ranged from 3.4–73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h.

Synonyms	瑞德西韦代谢物
Molecular Weight	531.203
Formula	C12H16N5O13P3
CAS No.	1355149-45-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Pedersen N C , Perron M , Bannasch M , et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis[J]. Journal of Feline Medicine & Surgery, 2019.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GS-443902 1355149-45-9 DNA损伤和修复代谢蛋白酶体微生物学细胞周期 DNA/RNA Synthesis Drug Metabolite HCV Protease Nucleoside Antimetabolite/Analog RSV SARS-CoV SARS coronavirus Hepatitis C virus Remdesivir metabolite HCV Respiratory syncytial virus metabolite RdRp RNA-dependent GS-5734 GS-441524 GS-441524 triphosphate Remdesivir RNA-polymerases GS443902 Inhibitor triphosphate inhibit GS 443902 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.