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Evans blue

Catalog No. T0313 CAS 314-13-6

Synonyms: Direct Blue 53, C.I. 23860

Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).

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Evans blue, CAS 314-13-6

Pack Size	Availability	Price/USD
50 mg	In stock	$ 41.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 80.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 98.85%

Purity: 85.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).
Targets&IC50	Glutamate uptake (vesicular):87 nM
In vitro	Evans Blue is found to be inhibiting DNA binding of NF-κB at a low concentration of 100 μM[1]. It has proven over the years to be a dependable stain for microscopic determination of cell death[2]. Evans Blue is also a known blocker of a subset of a-amino-3-hydroxy-5-methyl-isoxazole/kainate receptors (IC50=355 nM) for the subunit combination GluR1,2[5]. Evans blue is the first known δ-subunit-specific antagonist of ENaC and activates large-conductance Ca2+-activated K+ channels in sheep bladder myocytes and cultured endothelial cells of human umbilical veins[5].
In vivo	Evans blue pretreatment could inhibit the mast cells degranulation and that may be the main mechanism for prevent animals from C48/80-triggered anaphylaxis and systemic inflammation[4]. Evans blue modulates the non-N-methyl-d-aspartate receptor in rat thalamic neurons, blocks the P2X-purinergic receptor in rat vas deferens, and inhibits the glutamate transporter in rat brain synaptic vesicles[6].

Synonyms	Direct Blue 53, C.I. 23860
Molecular Weight	960.78
Formula	C34H24N6Na4O14S4
CAS No.	314-13-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 104.1 mM

DMSO: 104.1 mM

References and Literature

1. Sharma RK, et al. Bioorg Med Chem Lett. 2004, 14(24):6123-7. 2. C. Jacyn Baker, et al. Plant Cell, Tissue and Organ Culture. 1994, 39(1):7-12. 3. Miller DL, et al. Ultrasound Med Biol. 2007, 33(12):1988-96. 4. Yu-Tong Chen, et al. FASEB Journal. 2016, 30(1): Supplement 723.10. 5. Roseth S, et al. Biochem Pharmacol. 1998, 56(9):1243-9.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Glutamine Metabolism Compound Library Bioactive Compound Library

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Related compounds with same targets

CX717 GYKI 53655 hydrochloride Talampanel LY3020371 hydrochloride CPCCOEt BMT-145027 VU0650786 Direct Blue 1

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Keywords

Evans blue 314-13-6 Neuroscience GluR Direct Blue 53 Direct Blue-53 C.I. 23860 inhibit Inhibitor Direct Blue53 inhibitor

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