store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 29.00 | |
5 mg | In stock | Inquiry | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 69.00 |
Description | EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
Targets&IC50 | TRPP3 channel:10.5 μM |
In vitro | It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively[1]. The number of autophagic vacuoles increases dramatically in the HAE and HPE groups after EIPA treatment compares with the HAN and HPN groups. EIPA regulates the initiation and maturation of the autophagy associated with amino acids in IEC-18 cells [2]. In addition, the uptake of cinnamoylphenazine (CA-PZ) and neutral red (NR) is inhibited by EIPA [3]. |
Cell Research | The effect of EIPA alone (without alanine or proline) is also examined in both control (DMEM cultured cells) and amino acid-starved cells. The cells are incubated for 6 h in DMEM containing 5% FBS and either 0 or 0.3 mM EIPA (labeled QNN and QNE, respectively), HBSS containing either 0 or 0.3 mM EIPA (labeled HNN and HNE, respectively), HBSS with 1.0 mM alanine (labeled HAN) or 0.5 mM proline (labeled HPN), HBSS with 1.0 mM alanine and 0.3 mM EIPA (labeled HAE), and HBSS with 0.5 mM proline and 0.3 mM EIPA (labeled HPE) [2]. |
Synonyms | L593754, MH 12-43 |
Molecular Weight | 299.76 |
Formula | C11H18ClN7O |
CAS No. | 1154-25-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 135 mg/mL (450.36 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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EIPA 1154-25-2 Membrane transporter/Ion channel Sodium Channel TRP/TRPV Channel colon carcinoma IEC-18 NHE3 renal failure IBDs Cation channel ddY strain mice MKN28 L-593754 Autophagy gastric cancer Inhibitor neuron pancreatic carcinoma inhibit L593754 IECs TRP Channel L 593754 Sodium-hydrogen Exchanger Prostaglandin Receptor Cyclooxygenase COX Na+/H+ Exchanger (NHE) zinc Transient receptor potential channels calcium kainite MH 12-43 Sodium/hydrogen Exchanger inhibitor