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Dexamethasone Phosphate disodium

Catalog No. T0947L CAS 2392-39-4

Synonyms: EGP-437, EGP437. Dex-Phos, EGP 437

Dexamethasone Phosphate disodium (EGP437. Dex-Phos) is a water-soluble form of the synthetic glucocorticoid dexamethasone.

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Dexamethasone Phosphate disodium Chemical Structure

Dexamethasone Phosphate disodium, CAS 2392-39-4

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50 mg	In stock	$ 30.00
100 mg	In stock	$ 41.00

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Purity: 99.88%

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Storage & Solubility Information

Description	Dexamethasone Phosphate disodium (EGP437. Dex-Phos) is a water-soluble form of the synthetic glucocorticoid dexamethasone.
In vitro	Dexamethasone regulates multiple transcription factors, including activator protein-1, nuclear factor-AT, and nuclear factor-kB, resulting in the activation and repression of key genes involved in the inflammatory response[1]. Dexamethasone potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells with EC50 of 2.2 nM. Dexamethasone (EC50=36 nM) induces transcription of the β2-receptor is found to correlate with glucocorticoid receptor (GR) DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release. Dexamethasone (IC50=0.5 nM) inhibits a 3×κB (NF-κB, IκBα, and I-κBβ), which is associated with inhibition of GM-CSF release.
In vivo	Administering Dexamethasone at 2×5 mg/kg effectively reduces lipopolysaccharide (LPS)-induced inflammation. This treatment, particularly a single 10 mg/kg dose (i.p.), significantly lessens granulocyte mobilization and the spontaneous production of oxygen radicals in comparison to animals exposed to LPS and treated with saline. These benefits are pronounced when Dexamethasone is given both 1 hour before and after LPS inhalation, with granulocyte numbers in BALF dropping to those seen in healthy animals (exposed to an aerosol of water)[3]. However, rats receiving Dexamethasone show reduced food consumption and weight compared to control rats, and exhibit lower weights even compared to pair-fed rats with similar food intakes. Continuous Dexamethasone treatment for five days results in notable liver enlargement (+42%) and an increased liver-to-body weight ratio (+65%), while the gastrocnemius muscle's wet weight diminishes by 20% without affecting the muscle to body weight ratio (g/100 g body weight), suggesting muscle weight reduction aligns with overall body weight loss.

Synonyms	EGP-437, EGP437. Dex-Phos, EGP 437
Molecular Weight	516.4
Formula	C22H28FNa2O8P
CAS No.	2392-39-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 100 mg/mL (193.65 mM)

DMSO: 1 mg/mL (1.94 mM), Sonication and heating to 80℃ are recommended.

References and Literature

1. Torres MP, Entwistle F, Coote PJ. Effective immunosuppression with dexamethasone phosphate in the Galleria mellonella larva infection model resulting in enhanced virulence of Escherichia coli and Klebsiella pneumoniae. Med Microbiol Immunol. 2016 Aug;205(4):333-43. doi: 10.1007/s00430-016-0450-5. PubMed PMID: 26920133; PubMed Central PMCID: PMC4939170. 2. Patane MA, Schubert W, Sanford T, Gee R, Burgos M, Isom WP, Ruiz-Perez B. Evaluation of ocular and general safety following repeated dosing of dexamethasone phosphate delivered by transscleral iontophoresis in rabbits. J Ocul Pharmacol Ther. 2013 Oct;29(8):760-9. doi: 10.1089/jop.2012.0175. PubMed PMID: 23844757. 3. Martín-Sabroso C, Tavares-Fernandes DF, Espada-García JI, Torres-Suárez AI. Validation protocol of analytical procedures for quantification of drugs in polymeric systems for parenteral administration: dexamethasone phosphate disodium microparticles. Int J Pharm. 2013 Dec 15;458(1):188-96. doi: 10.1016/j.ijpharm.2013.09.026. PubMed PMID: 24120930. 4. Keeler GD, Durdik JM, Stenken JA. Effects of delayed delivery of dexamethasone-21-phosphate via subcutaneous microdialysis implants on macrophage activation in rats. Acta Biomater. 2015 Sep;23:27-37. doi: 10.1016/j.actbio.2015.05.011. PubMed PMID: 25985913.

Related compound libraries

This product is contained In the following compound libraries：

EMA Approved Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Endocrinology-Hormone Compound Library Clinical Compound Library NO PAINS Compound Library

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Keywords

Dexamethasone Phosphate disodium 2392-39-4 Endocrinology/Hormones Glucocorticoid Receptor Dexamethasone Phosphate EGP-437 inhibit Inhibitor Dexamethasone 21-phosphate disodium EGP437. Dex-Phos EGP437 EGP 437 inhibitor

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