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B022

Catalog No. T14491   CAS 1202764-53-1

B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins.

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B022 Chemical Structure
B022, CAS 1202764-53-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 68.00
5 mg In stock $ 168.00
10 mg In stock $ 247.00
25 mg In stock $ 418.00
50 mg In stock $ 612.00
100 mg In stock $ 786.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins.
Targets&IC50 NF-κB-inducing kinase (NIK):4.2 nM (Ki)
In vitro B022 treatment of Hepa1 cells (0 μM, 0.5 μM, 5 μM; 12 hours) can suppress NIK-induced p52 formation in a dose-dependent manner[1].
In vivo In STOP-NIK male mice (8 weeks old) infected with Ad-cre, B022 (30 mg/kg; intravenous injection; twice daily; for 10 days) completely prevents the lethal effects induced by abnormally high levels of hepatic NIK in mice. It inhibits the majority of the deteriorating effects caused by aberrant activation of hepatic NIK[1].
Molecular Weight 397.88
Formula C19H16ClN5OS
CAS No. 1202764-53-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (502.66 mM), Sonification is recommeded

TargetMolReferences and Literature

1. Ren X, et al. A small-molecule inhibitor of NF-κB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury. FASEB J. 2017 Feb;31(2):711-718. 2. Li Z, et al. Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo. J Med Chem. 2020;63(8):4388-4407. 3. Li X, et al. Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes. Mol Ther. 2020;28(11):2430-2441.

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Keywords

B022 1202764-53-1 NF-Κb NF-κB B-022 B 022 inhibitor inhibit

 

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