Powder: -20°C for 3 years | In solvent: -80°C for 1 year
B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 168.00 | |
10 mg | In stock | $ 247.00 | |
25 mg | In stock | $ 418.00 | |
50 mg | In stock | $ 612.00 | |
100 mg | In stock | $ 786.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins. |
Targets&IC50 | NF-κB-inducing kinase (NIK):4.2 nM (Ki) |
In vitro | B022 treatment of Hepa1 cells (0 μM, 0.5 μM, 5 μM; 12 hours) can suppress NIK-induced p52 formation in a dose-dependent manner[1]. |
In vivo | In STOP-NIK male mice (8 weeks old) infected with Ad-cre, B022 (30 mg/kg; intravenous injection; twice daily; for 10 days) completely prevents the lethal effects induced by abnormally high levels of hepatic NIK in mice. It inhibits the majority of the deteriorating effects caused by aberrant activation of hepatic NIK[1]. |
Molecular Weight | 397.88 |
Formula | C19H16ClN5OS |
CAS No. | 1202764-53-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (502.66 mM), Sonification is recommeded
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
B022 1202764-53-1 NF-Κb NF-κB B-022 B 022 inhibitor inhibit