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Amlodipine maleate

Catalog No. T21263 CAS 88150-47-4

Synonyms: Amlodipine (+-)-form maleate, Amvaz

Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.

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Amlodipine maleate, CAS 88150-47-4

Pack Size	Availability	Price/USD
500 mg	In stock	$ 42.00
1 g	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.4%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.
In vitro	Amlodipine maleate (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.[4] Amlodipine maleate (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% in A431 cells, respectively.[4] Amlodipine maleate (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.[4]
In vivo	Amlodipine maleate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.[4] Amlodipine maleate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.[5]

Synonyms	Amlodipine (+-)-form maleate, Amvaz
Molecular Weight	524.95
Formula	C24H29ClN2O9
CAS No.	88150-47-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 108.0 mg/mL (205.7 mM), Sonication is recommended.

References and Literature

1. Gottwald-Hostalek U, et al. Management of Hypertension With a Fixed-Dose (Single-Pill) Combination of Bisoprolol and Amlodipine. Clin Pharmacol Drug Dev. 2017 Jan;6(1):9-18. 2. van Zwieten PA. Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties. Clin Cardiol. 1994 Sep;17(9 Suppl 3):III3-6. 3. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease. Drugs. 1995;50(3):560-586. 4. Yoshida J, et al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004;492(2-3):103-112. 5. Okuyama Y, et al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018;41(2):80-87.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library EMA Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

Amlodipine maleate 88150-47-4 Membrane transporter/Ion channel Metabolism Calcium Channel Amlodipine Maleate Amlodipine (+-)-form Maleate Amlodipine (+-)-form maleate Amvaz inhibitor inhibit

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