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AF 12198 Acetate

Catalog No. T21644L CAS T21644L

Synonyms: AF 12198 Acetate (185413-30-3 Free base)

AF 12198 Acetate is a novel low molecular weight antagonist of IL-1

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AF 12198 Acetate, CAS T21644L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 697.00
5 mg	In stock	$ 1,470.00
10 mg	In stock	$ 1,980.00
25 mg	In stock	$ 2,950.00
50 mg	In stock	$ 3,980.00
100 mg	In stock	$ 5,360.00
1 mL * 10 mM (in DMSO)	In stock	$ 3,890.00

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Purity: 95.27%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AF 12198 Acetate is a novel low molecular weight antagonist of IL-1
Targets&IC50	IL-8:25 nM
In vitro	?In vitro, AF12198 inhibits IL-1-induced IL-8 production by human dermal fibroblasts with a half-maximal inhibition concentration or IC50 of 25 nM and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells with an IC50 of 9 nM[1].
In vivo	When given as an intravenous infusion to cynomolgus monkeys, AF12198 blocks ex vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6.?This is the first small molecule to show IL-1 receptor antagonist activity in vivo[1].?

Synonyms	AF 12198 Acetate (185413-30-3 Free base)
Molecular Weight	1955.17
Formula	C98H127N19O24
CAS No.	T21644L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (30.69 mM)

References and Literature

1. Akeson A L , Woods C W , Hsieh L C , et al. AF12198, a Novel Low Molecular Weight Antagonist, Selectively Binds the Human Type I Interleukin (IL)-1 Receptor and Blocks in Vivo Responses to IL-1[J]. Journal of Biological Chemistry, 1996, 271(48):30517.

Related compound libraries

This product is contained In the following compound libraries：

Immunology/Inflammation Compound Library Bioactive Compounds Library Max Cytokine Inhibitor Library NO PAINS Compound Library Inhibitor Library Bioactive Compound Library Peptide Compound Library

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Keywords

AF 12198 Acetate T21644L Immunology/Inflammation IL Receptor AF 12198 Acetate (185413-30-3 Free base) AF-12198 Acetate AF12198 Acetate 185413-30-3 185413-30-3 Free base inhibitor inhibit

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