Natural Product Library for HTS

Catalog No. L6000

Library Compound List Excel SDF

Natural products are compounds produced by organisms in nature. Their structures and functions have been selected and optimized during the long evolutionary process of nature, resulting in highly diverse structures through different processes such as oxidation and reduction, rearrangement reaction, cationic cyclization, condensation reactions, and pericyclic reactions.

These unique chemical structures endow natural products with target-specific binding ability and good biological activity. Therefore, natural products have become an important source for drug discovery of major disease treatments. Whenever a new game-changing drug emerges, it is usually, though not every time, accompanied by the discovery of a new type of natural product, which also promotes the development of medicinal chemistry and life sciences.

TargetMol’s Natural Product Library for HTS has a collection of 4320 carefully selected natural product monomers. These natural product monomers are widely sourced, structurally diversed and highly representative. They exist in natural sources extracted and purified from more than 2,900 kinds of Chinese medicinal herbs, animals and microorganisms, covering more than 500 different scaffolds and more than 1,000 target receptors, and most of the components have reached the purity of reference standards. In addtion, the library also contains many rare natural products with extremely high unit prices, which makes the library highly cost-effective. TargetMol’s Natural Product Library for HTS is a powerful tool for drug development, pharmacological research, stem cell differentiation, fingerprint research, quality research and other fields.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 4320 pure natural products and their derivatives with known biological activity for drug discovery, pharmacological study, stem cell differentiation, fingerprint study and quality research, and can be used for high throughput screening (HTS) and high content screening (HCS);
Documentation with clear source: isolated natural products from plant, animal, microorganism, etc.
Structurally diverse: 4320 natural products, including diverse types of structures, such as alkaloids, limonoids, sequiterpenes, diterpenes, pentacyclic triterpenes, sterols, and many other representatives which provide the structural diversity inherent in this group;
Detailed compound information with structure, solubility, target, activity, IC50 value, and biological activity description;
Cost-effective and competitive price to save your fundings.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Nature Biotechnology. 2021, 39(11): 1444-1452. 2. Immunity. 2023. 3. Nature Microbiology. 2023, 8(1): 121-134. 4. Nature Communications. 2022, 13(1): 1-15.. 5. Blood. 2021, 137(11): 1478-1490. 6. Nature Communications. 2019 Apr 23;10(1):1914. 7. Nature Communications. 2020, 11(1): 1-12. 8. Acta Pharmaceutica Sinica B. 2022. 9. Protein & Cell. 2017 Aug;8(8):618-622.

10. Engineering. 2023. 11. Bone Research. 2023, 11(1): 54. 12. Cancer Immunology Research. 2023: CIR-22-0483. 13. Redox Biology. 2022: 102229. 14. Journal of Cell Biology. 2022, 221(5): e202112024. 15. Clinical Cancer Research. 2020, 26(13): 3408-3419. 16. Chemical Science. 2022. 17. Cell & Bioscience. 2021, 11(1): 1-14. 18. Cell Reports. 2023, 42(12). 19. Journal of Translational Medicine. 2022, 20(1): 1-11.. 20. Biomedicine & Pharmacotherapy. 2024, 171: 116176. 21. Acta Pharmacologica Sinica. 2022: 1-15. 22. Cell Proliferation. 2022: e13214. 23. Cell Death & Disease,. 2020, 11(9): 1-12. 24. The American Journal of Chinese Medicine. 2020: 1-20. 25. International Journal of Molecular Sciences. 2021, 22(21): 12037. 26. Journal of Agricultural and Food Chemistry. 2023. 27. Viruses. 2023, 15(4): 891. 28. Acta Pharmaceutica Sinica B. 2020. 29. Journal of Chemical Information and Modeling. 2023. 30. Frontiers in chemistry. 2022, 10. 31. Food & Function. 2018, 9(11): 5536-5546. 32. Journal of Agricultural and Food Chemistry. 2021. 33. Cell Death Discovery. 2021, 7(1): 1-10. 34. Pharmaceuticals. 2023, 16(5): 767. 35. Bioorganic Chemistry. 114 (2021): 105043. 36. European Journal of Pharmaceutical Sciences. 2023: 106672.. 37. Plants-Basel. 2024, 13(2): 318.. 38. Cancer Science. 2021, 112(11): 4722. 39. Frontiers in Pharmacology. 2020, 11. 40. Journal of Cheminformatics. 2020, 12(1): 1-51. 41. Journal of Natural Products. 2022. 42. Neoplasia. 2020, 22(4): 179-191. 43. Journal of Chemical Information and Modeling. 2018 Aug 27;58(8):1518-1532. 44. Plos one. 2023, 18(4): e0281834. 45. Virology. 2022. 46. ChemMedChem. 2022: e202100719. 47. Veterinary Microbiology. 2021 Apr;255:109016. 48. Molecules. 2020, 25(4): 938. 49. Biomolecules. 2019 Jan 24;9(2). 50. Experimental and Therapeutic Medicine. 2021, 22(2): 1-13. 51. Pharmacology. 2020: 1-7. 52. Interdisciplinary Sciences, Computational Life Sciences. 2020, 12: 368-376. 53. Springer. 2020: 1-27. 54. bioRxiv. 2023: 2023.08. 31.555687.. 55. SSRN. 2023. 56. Preprints. 2019. 57. bioRxiv. 2021. 58. STAR Protocols. 2022: 101794. 59. bioRxiv. 2022. 60. Molecular Immunology. 2022, 147: 1-9. 62. Physical Sciences Reviews. 2019, 4(6). 63. Cell Stem Cell. 2022 Apr 29(4) 545–558. 64. Science Bulletin. 2022. 65. Science Translational Medicine. 2022, 14(656): eabn3231. 66. Science Advances. 2023, 9(9): eade3760. 67. Nature. 2020, 582: 289-293. 68. Nature Communications. 2023, 14(1): 1020.. 69. Nature Communications. 2023, 14(1): 2756.. 70. Nucleic Acids Research. 2021. 71. Nature Communications. 2023, 14(1): 7574. 72. Advanced Science. 2020, 7(16): 2000925. 73. Angewandte Chemie. 2021. 74. Protein & Cell. 2021, 12(11): 877-888. 75. Pharmacology & Therapeutics. (2021): 107930. 76. Nature Communications. 2021, 12(1): 1-12. 77. Li H, Sun Y, Yin H, et al.Virtual screening of natural products targeting ubiquitin-specific protease 7.Journal of Biomolecular Structure and Dynamics.2024: 1-8. 78. Duo L, Chen Y, Liu Q, et al.Discovery of Novel SOS1 Inhibitors Using Machine Learning.RSC Medicinal Chemistry.2024 79. Li X, Xiang C, Zhu S, et al.SNX8 enables lysosome reformation and reverses lysosomal storage disorder.Nature Communications.2024, 15(1): 2553.

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Library Composition

Endogenous Metabolite (1028)

Apoptosis (402)

Antibacterial (384)

Autophagy (256)

NF-κB (188)

Antibiotic (178)

Antifungal (137)

Antioxidant (118)

Reactive Oxygen Species (112)

COX (99)

Parasite (90)

P450 (72)

Influenza Virus (70)

TNF (67)

DNA/RNA Synthesis (65)

AChR (61)

HIV Protease (57)

AChE (57)

NO Synthase (55)

Anti-infection (52)

IL Receptor (50)

ERK (48)

Caspase (48)

p38 MAPK (47)

Calcium Channel (46)

PPAR (45)

Akt (44)

GABA Receptor (43)

Tyrosinase (42)

STAT (41)

MMP (37)

AMPK (37)

5-HT Receptor (34)

Virus Protease (34)

Ferroptosis (34)

Antifection (33)

PI3K (33)

Microtubule Associated (32)

Nrf2 (32)

BCL (32)

PKC (31)

Estrogen/progestogen Receptor (31)

ROS (31)

Topoisomerase (30)

JNK (29)

Dehydrogenase (29)

Immunology/Inflammation related (27)

Adrenergic Receptor (27)

Estrogen Receptor/ERR (27)

Lipoxygenase (27)

Potassium Channel (26)

NOS (26)

TRP/TRPV Channel (25)

HSV (25)

Prostaglandin Receptor (25)

Mitophagy (24)

P-gp (23)

PARP (23)

ribosome (23)

PDE (22)

ATPase (22)

Glucosidase (22)

Beta Amyloid (21)

Sodium Channel (20)

Antiviral (20)

Wnt/beta-catenin (18)

Mitochondrial Metabolism (18)

Dopamine Receptor (18)

HIF/HIF Prolyl-Hydroxylase (17)

HDAC (17)

Nucleoside Antimetabolite/Analog (17)

HBV (17)

Phosphatase (16)

Interleukin (16)

NMDAR (16)

Drug Metabolite (16)

iGluR (15)

MAO (15)

Amino Acids and Derivatives (15)

EGFR (15)

Adenosine Receptor (15)

Phospholipase (15)

mTOR (14)

JAK (14)

TLR (14)

SARS-CoV (14)

Histamine Receptor (14)

GluR (13)

Androgen Receptor (13)

Reductase (13)

VEGFR (12)

TGF-beta/Smad (12)

HCV Protease (12)

Opioid Receptor (12)

Cannabinoid Receptor (12)

Sirtuin (11)

CDK (11)

MAPK (11)

NOD (10)

Glucocorticoid Receptor (9)

Monoamine Oxidase (9)

GPR (9)

HMG-CoA Reductase (9)

HIF (9)

HSP (9)

PKA (9)

Fatty Acid Synthase (9)

transporter (9)

Chloride channel (9)

p53 (9)

BACE (8)

MEK (8)

Platelet aggregation (8)

LDL (8)

RAAS (8)

IκB/IKK (8)

FXR (8)

UGT (8)

PAFR (7)

Xanthine Oxidase (7)

Progesterone Receptor (7)

Carbonic Anhydrase (6)

Transferase (6)

Proteasome (6)

Aryl Hydrocarbon Receptor (6)

CaMK (6)

Reverse Transcriptase (6)

GSK-3 (6)

Indoleamine 2,3-Dioxygenase (IDO) (6)

Free radical scavengers (6)

Aromatase (5)

PTEN (5)

Epigenetic Reader Domain (5)

Lipid (5)

Retinoid Receptor (5)

IGF-1R (5)

FAAH (5)

NOD-like Receptor (NLR) (5)

Beta-Secretase (5)

HER (5)

Thyroid hormone receptor(THR) (5)

NADPH (5)

Gamma-secretase (5)

c-Met/HGFR (5)

Proton pump (5)

Arginase (5)

MRP (5)

Src (4)

DHFR (4)

ROR (4)

Syk (4)

DNA (4)

E1/E2/E3 Enzyme (4)

Integrin (4)

Serine/threonin kinase (4)

FGFR (4)

cell cycle arrest (4)

Cysteine Protease (4)

Liver X Receptor (4)

PGE Synthase (4)

cAMP (4)

IAP (4)

ATP Citrate Lyase (4)

FAK (4)

GST (4)

Histone Acetyltransferase (4)

ABC (4)

GPCR19 (4)

AhR (4)

CCR (4)

Tyrosine Kinases (4)

CXCR (4)

Serine Protease (4)

S6 Kinase (4)

Antifolate (4)

Trk receptor (3)

Serotonin Transporter (3)

Aminopeptidase (3)

Cell wall (3)

Acyltransferase (3)

Glutathione Peroxidase (3)

PDK (3)

PDGFR (3)

P2Y Receptor (3)

P2X Receptor (3)

CAT (3)

Ras (3)

Hedgehog/Smoothened (3)

DNA Methyltransferase (3)

Imidazoline Receptor (3)

Phosphorylase (3)

Bombesin Receptor (3)

Telomerase (3)

Amylase (3)

ATM/ATR (2)

gp120/CD4 (2)

S1P Receptor (2)

RSV (2)

Amylin Receptor (2)

PKM (2)

Thrombin (2)

Lipase (2)

LTR (2)

IRAK (2)

NADPH-oxidase (2)

Neurokinin receptor (2)

Histone Methyltransferase (2)

Smo (2)

DYRK (2)

Hydroxylase (2)

DNA Alkylator/Crosslinker (2)

Casein Kinase (2)

DPP-4 (2)

PAI-1 (2)

OAT (2)

PAK (2)

Monoamine Transporter (2)

DNA gyrase (2)

Aurora Kinase (2)

Norepinephrine (2)

Adiponectin receptor (2)

SGLT (2)

RANKL/RANK (2)

Glucokinase (2)

Leukotriene Receptor (2)

Glutathione reductase (2)

Bcr-Abl (2)

Pyroptosis (2)

Pim (2)

hCE (2)

Decarboxylase (2)

OCT (2)

Bradykinin Receptor (1)

Glucagon Receptor (1)

Factor Xa (1)

Epoxide Hydrolase (1)

MT Receptor (1)

stilbene oxidase (1)

PAD (1)

cholecystokinin (1)

Monocarboxylate transporter (1)

NPC1L1 (1)

Somatostatin (1)

Melatonin Receptor (1)

Transaminase (1)

Thrombopoietin Receptor (1)

GlyT (1)

Stearoyl-CoA Desaturase (SCD) (1)

ROS Kinase (1)

Adenylyl cyclase (1)

CFTR (1)

Hexokinase (1)

PD-1/PD-L1 (1)

Mdm2 (1)

advanced glycation end products (1)

DNA Alkylation (1)

Hydrogenase (1)

Histone Demethylase (1)

Raf (1)

IDO (1)

CRISPR/Cas9 (1)

RAR/RXR (1)

aconitase (1)

BCRP (1)

IFNAR (1)

PERK (1)

Oxytocin Receptor (1)

CaSR (1)

c-Myc (1)

Carboxypeptidase (1)

LPL Receptor (1)

Adenosine deaminase (1)

Survivin (1)

PLK (1)

Prolyl Endopeptidase (PREP) (1)

MyD88 (1)

IRE1 (1)

Dynamin (1)

CPT (1)

ALK (1)

MTH1 (1)

ATTECs (1)

CYP19A1 (1)

NMU2R (1)

Fas/FasL (1)

FLT (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty