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Zymostenol

Catalog No. T35321 CAS 566-97-2

Synonyms: delta(8)-Cholestenol, 5a-Cholest-8-en-3b-ol, Δ8-Cholesterol

Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.

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Zymostenol, CAS 566-97-2

Pack Size	Availability	Price/USD
5 mg	35 days	$ 263.00
10 mg	35 days	$ 468.00
25 mg	35 days	$ 987.00
50 mg	35 days	$ 1,930.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.
Targets&IC50	RORγ:1 μM(EC50)
In vitro	Zymostenol (12-104 μM) promotes the formation of myelin basic protein-positive (MBP+) oligodendrocytes in mouse ectodermal stem cell-derived oligodendrocyte progenitors.[2] Zymostenol (20 μM, 3 days) arrests the MCF-7 cell cycle in the G0-G1 phase.[3]

Synonyms	delta(8)-Cholestenol, 5a-Cholest-8-en-3b-ol, Δ8-Cholesterol
Molecular Weight	386.65
Formula	C27H46O
CAS No.	566-97-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hu X, et al. Sterol metabolism controls TH17 differentiation by generating endogenous RORγ agonists Nat. Chem Biol. 2015;11(9), 141-147. 2. Hubler Z, et al. Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature. 2018;560(7718):372-376. 3. Payré B, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008;7(12):3707-3718. 4. Kaman WE, et al. Gramicidin A is hydrolyzed by a d-stereospecific peptidase produced by Bacillus anthracis. Environ Microbiol Rep. 2022;14(4):570-576.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zymostenol 566-97-2 Metabolism ROR Endogenous Metabolite delta(8)-Cholestenol 5a-Cholest-8-en-3b-ol Δ8-Cholesterol delta8-Cholesterol inhibitor inhibit

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