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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9623 | RORγt inverse agonist 13 | ROR | |
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1]. | |||
T12753 | RORγt Inverse agonist 6 | ROR | |
RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases. | |||
T39038 | RORγt inhibitor 1 | ||
RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC 50 value of 1 nM. | |||
T39720 | RORγt inverse agonist 23 | ||
RORγt inverse agonist 23, an orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist, is a potent and selective RORγt inverse agonist. | |||
T12751 | RORγt agonist 1 | Others | |
RORγt agonist 1 is a potent, orally bioavailable agonist of RORγt(EC50 of 20.8 nM). | |||
T40043 | RORγt Inverse agonist 10 | ||
RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel... | |||
T12754 | RORγt Inverse agonist 8 | ROR | |
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM). | |||
T12755 | RORγt Inverse agonist 2 | Others | |
RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM). | |||
T12752 | RORγt Inverse agonist 3 | Others | |
RORγt Inverse agonist 3 is a potent, selective and orally active inverse agonist of RORγ(EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively). | |||
T64017 | RORγt agonist 3 | ||
RORγt agonist 3 is a potent agonist of RORγt. RORγt agonist 3 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus increases lymphocyte cytotoxicity. rorγt agonist 3 blocks the produ... | |||
T72595 | RORγt inhibitor 2 | ||
RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are mediated by RORγt. | |||
T72596 | RORγt modulator 5 | ||
RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM. This compound holds promise for the treatment of diseases mediated by RORγ, including inflammatory, metabolic, and autoimmun... | |||
T63124 | RORγt modulator 4 | ||
RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen. | |||
T64140 | RORγt agonist 2 | ||
RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus enhances lymphocyte cytotoxicity. rorγt agonist 2 exhibits an inhib... | |||
T63609 | RORγt modulator 3 | ||
RORγt modulator 3 is a modulator of retinol-related orphan receptor γt (RORγt) and can be used to study RORγt-mediated diseases such as pain, COPD, inflammation, asthma, colitis, multiple sclerosis, rheumatoid arthritis,... | |||
T63678 | RORγt modulator 2 | ||
RORγt modulator 2 is a modulator of retinol-related orphan receptor γt (RORyt) (IC50<50 nM) and can be used in the study of RORγt-mediated diseases such as pain, inflammation, asthma, rheumatoid arthritis, COPD, multiple... | |||
T63874 | RORγt inverse agonist 28 | ||
RORγt inverse agonist 28 is a potent RORγt inverse agonist. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has shown research potential... | |||
T62564 | RORγt inverse agonist 30 | ||
RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist (IC50: 46 nM). Targeting the nuclear receptor RORγt is effective in the treatment of autoimmune diseases. | |||
T62956 | RORγt inverse agonist 29 | ||
RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM. RORγt inverse agonist 29 can be used in the study of autoimmune diseases such as skin inflammation and pso... | |||
T62462 | RORγt/DHODH-IN-2 | ||
RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor that can be used in the study of inflammatory bowel disease (IBD). |