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Search Results for " rorγt "

20

Compounds

Cat No. Product Name Synonyms Targets
T9623 RORγt inverse agonist 13 ROR
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].
T12753 RORγt Inverse agonist 6 ROR
RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.
T39038 RORγt inhibitor 1
RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC 50 value of 1 nM.
T39720 RORγt inverse agonist 23
RORγt inverse agonist 23, an orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist, is a potent and selective RORγt inverse agonist.
T12751 RORγt agonist 1 Others
RORγt agonist 1 is a potent, orally bioavailable agonist of RORγt(EC50 of 20.8 nM).
T40043 RORγt Inverse agonist 10
RORγt Inverse agonist 10 is a highly potent and orally bioavailable compound that acts as an antagonist for the retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt). With an IC50 of 51 nM, it effectivel...
T12754 RORγt Inverse agonist 8 ROR
RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).
T12755 RORγt Inverse agonist 2 Others
RORγt Inverse agonist 2 is a selective, orally active inverse agonist of RORγt(EC50 of 119 nM).
T12752 RORγt Inverse agonist 3 Others
RORγt Inverse agonist 3 is a potent, selective and orally active inverse agonist of RORγ(EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively).
T64017 RORγt agonist 3
RORγt agonist 3 is a potent agonist of RORγt. RORγt agonist 3 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus increases lymphocyte cytotoxicity. rorγt agonist 3 blocks the produ...
T72595 RORγt inhibitor 2
RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are mediated by RORγt.
T72596 RORγt modulator 5
RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM. This compound holds promise for the treatment of diseases mediated by RORγ, including inflammatory, metabolic, and autoimmun...
T63124 RORγt modulator 4
RORγt modulator 4 is a RORγt modulator that regulates IL-17A production activity in cells derived from mouse spleen.
T64140 RORγt agonist 2
RORγt agonist 2 is a potent agonist of RORγt. RORγt agonist 2 induces Th17 cell differentiation, increases levels of pro-inflammatory cytokines and thus enhances lymphocyte cytotoxicity. rorγt agonist 2 exhibits an inhib...
T63609 RORγt modulator 3
RORγt modulator 3 is a modulator of retinol-related orphan receptor γt (RORγt) and can be used to study RORγt-mediated diseases such as pain, COPD, inflammation, asthma, colitis, multiple sclerosis, rheumatoid arthritis,...
T63678 RORγt modulator 2
RORγt modulator 2 is a modulator of retinol-related orphan receptor γt (RORyt) (IC50<50 nM) and can be used in the study of RORγt-mediated diseases such as pain, inflammation, asthma, rheumatoid arthritis, COPD, multiple...
T63874 RORγt inverse agonist 28
RORγt inverse agonist 28 is a potent RORγt inverse agonist. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has shown research potential...
T62564 RORγt inverse agonist 30
RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist (IC50: 46 nM). Targeting the nuclear receptor RORγt is effective in the treatment of autoimmune diseases.
T62956 RORγt inverse agonist 29
RORγt inverse agonist 29 is a potent, selective, orally active RORγt inverse agonist with an IC50 value of 21 nM. RORγt inverse agonist 29 can be used in the study of autoimmune diseases such as skin inflammation and pso...
T62462 RORγt/DHODH-IN-2
RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor that can be used in the study of inflammatory bowel disease (IBD).
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TargetMol