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α-Vitamin E

Name: α-Vitamin E
Brand: TargetMol
SKU: T1648
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Vitamin E, D-α-Tocopherol, Alpha-Tocopherol, 5,7,8-Trimethyltocol, (+)-alpha-Tocopherol) Copy Product Info

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Synonyms: Vitamin E, D-α-Tocopherol, Alpha-Tocopherol, 5,7,8-Trimethyltocol, (+)-alpha-Tocopherol

Catalog No. T1648 Copy Product Info

Purity: 99.89%

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α-Vitamin E is a naturally occurring form of vitamin E with antioxidant and anti-inflammatory activity. α-Vitamin E can be used in research on oxidative stress, lipid peroxidation, membrane damage, and inflammation-related diseases.

Cas No. 59-02-9

Pack Size	Price	USA Stock	Global Stock	Quantity
50 mg	$38	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Color:Transparent to Yellow

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Product Introduction

Bioactivity

Description	α-Vitamin E is a naturally occurring form of vitamin E with antioxidant and anti-inflammatory activity. α-Vitamin E can be used in research on oxidative stress, lipid peroxidation, membrane damage, and inflammation-related diseases.
Targets & IC50	J774 cells:> 500 μM, Erythrocyte:3.658 μg/mL, ERα (mouse):> 500 nM (EC50), MT-4 cells:165 μM, THP-1 cells:> 500 μM, MCF-7 cells:> 300 μM, RPMI8226 cells:> 300 μM, HepG2 cells:> 300 μM, U-937 cells:100 μM, HL-60 cells:255 μM
In vitro	Methods: TC-1 mouse tumor cells (HPV16 E7+) were treated with α-Vitamin E (25, 50 μM) for 18 hours. Apoptosis and necrosis were detected by flow cytometry (Annexin V/7AAD staining). Results:α-Vitamin E induced TC-1 cell death in a concentration-dependent manner. At the high concentration (50 μM), the proportion of necrotic cells significantly increased. [1]
In vivo	Methods: C57BL/6 mice were subcutaneously inoculated with TC-1 cells.α-Vitamin E (2 mg/kg per dose) was administered via intraperitoneal injection starting on day 10 post-tumor inoculation, with subsequent injections on days 10, 12, and 14. Monitoring continued until approximately day 25. Results: Tumor volumes in the α-Vitamin E-treated group were significantly smaller than those in the control group. [1]
Synonyms	Vitamin E, D-α-Tocopherol, Alpha-Tocopherol, 5,7,8-Trimethyltocol, (+)-alpha-Tocopherol
Cell Research	For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I. (Only for Reference)

Chemical Properties

Molecular Weight	430.71
Formula	C₂₉H₅₀O₂
Cas No.	59-02-9
Smiles	CC1=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C)C(O)=C1C
Relative Density.	0.95g/mLat 25°C(lit.)

Storage & Solubility Information

Storage

Keep away from direct sunlight,Store under nitrogen Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 262.5 mg/mL (609.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.2 mg/mL (2.79 mM), Solution.

Saline: 25 mg/mL (58.04 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3217 mL	11.6087 mL	23.2175 mL	116.0874 mL
5 mM	0.4643 mL	2.3217 mL	4.6435 mL	23.2175 mL
10 mM	0.2322 mL	1.1609 mL	2.3217 mL	11.6087 mL
20 mM	0.1161 mL	0.5804 mL	1.1609 mL	5.8044 mL
50 mM	0.0464 mL	0.2322 mL	0.4643 mL	2.3217 mL
100 mM	0.0232 mL	0.1161 mL	0.2322 mL	1.1609 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: α-Vitamin E chemical structure | α-Vitamin E in vivo | α-Vitamin E in vitro | α-Vitamin E formula | α-Vitamin E molecular weight