virulence — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10933	D-Cysteine		Endogenous Metabolite , Antibacterial
	D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of the growth of E. coli. D-cysteine is mediated by D-amino acid oxidase to produce H2S, and is a neuroprotective agent against cerebellar ataxia. D-cystein...		Endogenous Metabolite , Antibacterial
T8507	MAC-545496		Antibacterial
	MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent.		Antibacterial
T20711	Hemipyocyanine	528-71-2	Amylase
	Hemipyocyanine (528-71-2) is the virulence factor of Gram-negative, aerobic rod bacterium Pseudomonas aeruginosa. Hemipyocyanine is an α-Amylase inhibitor.		Amylase
T3603	Sodium lauryl sulfoacetate	Sodium houttuyfonate	NF-κB , MAPK
	Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.		NF-κB , MAPK
T7283	Sodium lauroyl-α-hydroxyethyl sulfonate		NF-κB , MAPK
	Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.		NF-κB , MAPK
T9208	1,3,6,8-Tetrahydroxynaphthalene	T4HN,1,3,6,8-THN,naphthalene-1,3,6,8-tetrol	Others
	1,3,6,8-Tetrahydroxynaphthalene (T4HN) is a key precursor of 1,8-dihydroxynaphthalene-melanin, an important virulence factor in pathogenic fungi, where T4HN is believed to be the direct product of pentaketide synthases		Others
T37744	N-octanoyl-L-Homoserine lactone	C8-HSL,N-octanoyl-L-Homoserine lactone,OHL	Antibacterial
	N-octanoyl-L-Homoserine lactone (C8-HSL) is a diffusible exogenous Yersinia pestis population-sensing molecule that modulates LcrV virulence factors, controls gene expression by participating in population sensing, and a...		Antibacterial
T78226	Methyl 2-amino-5-bromobenzoate	Methyl 5-Bromoanthranilate	HCV Protease , Antifungal
	Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) is a hepatitis C virus NS5b RNA polymerase inhibitor with antimicrobial activity that inhibits Pseudomonas aeruginosa infections and is involved in the producti...		HCV Protease , Antifungal
T37341	N-Acetyltyramine		Antibacterial
	N-acetyltyramine is a metabolite of the biogenic amine tyramine . It enhances cytotoxicity of doxorubicin in resistant P388 murine leukemia cells with an IC50 value of 0.13 μg/ml compared with an IC50 value of 0.48 μg/ml...		Antibacterial
T22297	Clindamycin hydrochloride monohydrate	Clindamycin alcoholate	Antibiotic
	Clindamycin hydrochloride monohydrate (Clindamycin alcoholate) is a protein synthesis inhibitor used orally, capable of diminishing virulence factor expression in Staphylococcus aureus at sub-minimum inhibitory concentra...		Antibiotic
T125120	Cyclo(L-Pro-L-Val)		IκB/IKK , NOS , NF-κB , COX , Antibacterial
	Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microo...		IκB/IKK , NOS , NF-κB , COX , Antibacterial
T14043	4-(tert-Butyl)-benzhydroxamic Acid		Others
	4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with...		Others
T10909	Cyclic-di-GMP	c-di-GMP,cyclic diguanylate,5GP-5GP	Others
	Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species.		Others
T70436	BMS 188745 Potassium Salt
	BMS 188745 Potassium Salt inhibits the biosynthesis of the Staphylococcus aureus virulence factor staphyloxanthin via inhibition of dehydrosqualene synthase (CrtM).
T29677	Aerobactin
	Aerobactin, as a bacterial iron chelating agent (siderophore), can be found in E. coli. It is a virulence factor that can enable E. coli to sequester iron in iron-poor environments.
T37912	Furanone C-30
	Synthetic furanone bacterial quorum sensing inhibitor. Inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro. Also inhibits bacterial quorum sensing...
T76107	Urease
	Urease is produced by many types of bacteria and is an effective virulence factor for some pathogenic bacteria. Urease is also central to the metabolism and virulence of Helicobacter pylori, helping it colonize the stoma...
T36854	Pheleuin
	Pheleuin is a pyrazinone derivative synthesized from a dipeptide aldehyde. Although the biological activity of this compound has not been reported, similar diketopiperazines are known to inhibit calpain and/or regulate S...
T15587	Inz-5		Others
	Inz-5 is a fungal-selective inhibitor of mitochondrial cytochrome bc1. Inz-5 impairs fungal virulence. It also prevents the evolution of drug resistance.		Others
T69957	Quoromycin
	Quoromycin is a novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vu...