steatohepatitis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8732	CTPI-2		Others , Mitochondrial Metabolism
	CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha...		Others , Mitochondrial Metabolism
T2088	APD668	APD 668	GPR , P450 , Potassium Channel
	APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.		GPR , P450 , Potassium Channel
T27061	CP-24879 hydrochloride	CP-24879 HCl	Others
	CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an...		Others
T31964	Glycolithocholic acid	Lithocholic acid glycine conjugate,Lithocholylglycine	Others
	Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.		Others
T77099	Nimacimab	JNJ 2463,RYI-018	Others
	Nimacimab is a recombinant humanized monoclonal antibody. It can improve diabetes and non-alcoholic steatohepatitis.		Others
T64334	Glycolithocholic acid, sodium salt		Others
	Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s...		Others
T14301	Apararenone	MT-3995	Glucocorticoid Receptor
	Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.		Glucocorticoid Receptor
T9186	Ervogastat	PF-06865571	Transferase
	Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).		Transferase
T76700	Simtuzumab	GS 6624,AB 0024	Monoamine Oxidase
	Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato...		Monoamine Oxidase
T77059	Leronlimab	PRO 140	CCR
	Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronl...		CCR
T37526	2-Oleoylglycerol	2-Oleoyl Glycerol,2-OG,2-Monoolein	GPR
	2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglyce...		GPR
T67974	Berberine ursodeoxycholate	HTD1801,BUDCA
	Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly red...
T17236	Volixibat	SHP626,LUM002	Others
	Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.		Others
T74421	Pemvidutide
	Pemvidutide, a dual GLP-1R/GCGR agonist, significantly lowers body weight, liver fat, and serum lipids, holding promise for non-alcoholic steatohepatitis (NASH) and obesity research [1].
T78297	Aldafermin	NGM282
	Aldafermin (NGM282), an analog of fibroblast growth factor 19, is utilized in the investigation of nonalcoholic steatohepatitis (NASH) [1].
T11661	INT-767		FXR , GPCR19
	INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.		FXR , GPCR19
T81802	MGAT2-IN-4
	MGAT2-IN-4 (compound 33) serves as a monoacylglycerol acyltransferase 2 (MGAT2) inhibitor, exhibiting liver metabolic stability. This compound is applicable in obesity, diabetes, and non-alcoholic steatohepatitis (NASH) ...
T35636	SHS4121705
	SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis...
T76278	Efinopegdutide
	Efinopegdutide (JNJ-64565111) is a potent dual agonist for the glucagon-like peptide-1 (GLP-1) and glucagon receptors (GluR), showing efficacy in activating both receptors. It has potential applications in the research o...
T63876	TRβ agonist 1
	TRβ Agonist 1, a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, demonstrates an EC50 value of 21 nM. It is useful in the research of dyslipidemia, nonalcoholic steatohepatitis (NASH), and resi...