pyruvate — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8030	Ethyl pyruvate		Apoptosis , Antioxidant
	Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions.		Apoptosis , Antioxidant
T7717	Sodium 2-oxopropanoate	Sodium pyruvate	Reactive Oxygen Species , Endogenous Metabolite
	Sodium 2-oxopropanoate (Sodium pyruvate) is a antioxidant potentially used to treatment of chronic obstructive pulmonary disease.		Reactive Oxygen Species , Endogenous Metabolite
T32221	Isoniazid pyruvate	NSC-97221,BRN 0185611,NSC97221,NSC 97221,L 1011
	Isoniazid pyruvate is a metabolite of isoniazid. Isoniazid (Laniazid, Nydrazid), also known as isonicotinylhydrazine (INH), is an organic compound that is the first-line medication in prevention and treatment of tubercul...
T76143	Pyruvate oxidase
	Pyruvate oxidase (PoxB), a thiamine pyrophosphate-dependent enzyme, performs the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide, and water. This enzyme plays a crucial role in bacterial metabol...
T76115	Pyruvate kinase
	Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] .
T80060	Pyruvate carboxylase		Endogenous Metabolite
	Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP. This enzyme is crucial for regulating whole-body energetics, influencing...		Endogenous Metabolite
T61961	Pyruvate Carboxylase-IN-2
	Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC). In cell lysate-based and cell-based PC activity assays, Pyruvate Carbo...
T60341	Pyruvate Carboxylase-IN-1
	Pyruvate Carboxylase-IN-1 (compound 37), a natural analog of erianin, is a potent inhibitor of pyruvate carboxylase (PC), exhibiting inhibitory concentrations (IC50) of 0.204 μM and 0.104 μM in cell lysate-based and cell...
T12499	PKR-IN-2		PKM
	PKR-IN-2 is a activator of pyruvate kinase (PKR).		PKM
T6816	DASA-58		PKM
	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.		PKM
T4223	Mitapivat	PKR-IN-1	PKM
	Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.		PKM
T1768	7ACC2		Mitochondrial Metabolism , Monocarboxylate transporter
	7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.		Mitochondrial Metabolism , Monocarboxylate transporter
T11765	KPLH1130		Dehydrogenase , PDK
	KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.		Dehydrogenase , PDK
T17224	VER-246608		Dehydrogenase , PDK
	VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an...		Dehydrogenase , PDK
T2447	AZD7545		Dehydrogenase
	AZD7545 is a potent PDHK inhibitor.		Dehydrogenase
T31976	Glymidine sodium		Others
	Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.		Others
T22350	JX06		Apoptosis , Dehydrogenase , PDK
	JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.		Apoptosis , Dehydrogenase , PDK
T0809	Dicoumarol	Dicumarol	Dehydrogenase , NADPH , PDK
	Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t...		Dehydrogenase , NADPH , PDK
T7214	TEPP-46	ML265	PKM
	TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .		PKM
T3604	Sodium dichloroacetate	Sodium Dichloroacetate,DCA,BCA,bichloroacetic acid,Sodium dichloroacetate (DCA)	Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK
	Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion chann...		Apoptosis , Dehydrogenase , Reactive Oxygen Species , PDK