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TEPP-46

Catalog No. T7214 CAS 1221186-53-3

Synonyms: ML265

ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .

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TEPP-46, CAS 1221186-53-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ML265 is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .
In vivo	At 50 mg/kg, ML-265 has been shown to reduce tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung carcinoma[1]

Synonyms	ML265
Molecular Weight	372.46
Formula	C17H16N4O2S2
CAS No.	1221186-53-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (134.24 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Walsh M J , Brimacombe K R , Anastasiou D , et al. ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model[M]// Probe Reports from the NIH Molecular Libraries Program. PubMed, 2009. 2. Palsson-Mcdermott E , Curtis A , Goel G , et al. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages[J]. Cell Metabolism, 2015, 21(1):65-80.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Lipid Metabolism Compound Library Glutamine Metabolism Compound Library Anti-Metabolism Disease Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Bioactive Compound Library

Related Products

Related compounds with same targets

DL-Serine TEPP-46 DASA-58 WAY-332616 Mitapivat PKM2-IN-1 PKR-IN-2 Shikonin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TEPP-46 1221186-53-3 代谢 PKM TEPP46 TEPP 46 Pyruvate Kinase ML 265 ML-265 Inhibitor ML265 inhibit inhibitor

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