potentials — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22514	4F 4PP oxalate		5-HT Receptor
	4F 4PP oxalate is a 5-HT2A antagonist.		5-HT Receptor
T3478	Ro 67-7476		GluR
	Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.		GluR
T8195	Lotusine		Others
	Lotusine is a pure alkaloid extracted from the Nelumbo nucifera Gaertn. It shows effects on the action potentials in the myocardium and slow inward current in cardiac Purkinje fibers.		Others
T4960	VASICINE		Anti-infection , AChR
	Vasicine is oxytocic and abortifacient agents.Vasicine, a potential natural cholinesterase inhibitor, has been in development for treatment of Alzheimer's disease. Vasicine can regulate the inflammatory reaction, have gr...		Anti-infection , AChR
TN1727	Helichrysetin		Apoptosis , HIV Protease
	Helichrysetin has mild anti-HIV-1 PR activity. Helichrysetin has great potentials for development as an anticancer agent, it has cytotoxic effect on four selected cancer cell lines, A549, MCF-7, Ca Ski, and HT-29.		Apoptosis , HIV Protease
T17197	UCL 2077
	UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker，with IC50 of 500 nM in hippocampal neurons in culture, having minima...
T4440	Saclofen		GABA Receptor
	Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the function...		GABA Receptor
T8944	TTA-A2		Calcium Channel
	TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ...		Calcium Channel
T8899	Metipranolol		Adrenergic Receptor
	Metipranolol (Betamann) is a type of β- Adrenergic receptors（ β- A potent antagonist of adrenergic receptor on guinea pig atria β 1- Adrenergic receptors and rat uterus β The 2-adrenergic receptor exhibited the beta bloc...		Adrenergic Receptor
T38192	Unifiram		Others
	Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...		Others
T29748	AHR-12234
	AHR-12234 affects cardiac action potentials.
T30892	Chlordene	AI3-15150,AI3 15150,AI315150
	Chlordene, as a polychlorinated flame retardant, has bioaccumulation and biomagnification potentials.
T26092	Risotilide
	Risotilide is a voltage-dependent potassium channel inhibitor. It can prolong cardiac action potentials and refractory periods.
T36068	Brevetoxin B
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junct...
T68361	Asocainol hydrochloride
	Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also i...
T4550L	Ajmaline hydrochloride
	Ajmaline hydrochloride is an alkaloid found in the root of Rauwolfia serpentina, and other plant sources. It is a class of Ia antiarrhythmic agent that apparently works by changing the shape and threshold of cardiac acti...
TP1531	Guangxitoxin 1E
	Guangxitoxin 1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials.
T81957	Lacto-N-triose II
	Lacto-N-triose II, a core structural unit of human milk oligosaccharides (HMOs), possesses nutraceutical potentials and is utilized in the synthesis of complex HMOs [1].
TN5463	Leachianone G
	Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Le...
T78489	Lotusine hydroxide
	Lotusine (hydroxide), a pure alkaloid isolated from the green seed embryos of Nelumbo nucifera Gaertn, influences action potentials in myocardial tissue and the slow inward current in cardiac Purkinje fibers [1].