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UCL 2077

Catalog No. T17197 CAS 918311-87-2

UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker，with IC50 of 500 nM in hippocampal neurons in culture, having minimal effects on Ca2+ channels, action potentials, input resistance, and the medium afterhyperpolarization.

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UCL 2077, CAS 918311-87-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 81.00
2 mg	In stock	$ 117.00
5 mg	In stock	$ 167.00
10 mg	In stock	$ 239.00
25 mg	In stock	$ 432.00
50 mg	In stock	$ 639.00
100 mg	In stock	$ 890.00
500 mg	In stock	$ 1,830.00
1 mL * 10 mM (in DMSO)	In stock	$ 185.00

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Purity: 99.38%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	350.46
Formula	C25H22N2
CAS No.	918311-87-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (142.67 mM)

References and Literature

1. Shah MM, et al. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol Pharmacol. 2006 Nov;70(5):1494-502. 2. Soh H, et al. The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol Pharmacol. 2010 Dec;78(6):1088-95.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

UCL 2077 918311-87-2 Inhibitor UCL2077 inhibit UCL-2077 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.