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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8408 | GKT136901 | AK120765 | NADPH-oxidase , NADPH |
GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite | |||
T0626 | Uric Acid | 2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate | Reactive Oxygen Species , Endogenous Metabolite , Phosphorylase |
Uric Acid (Lithic acid) is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE ... | |||
T4890 | 3-Nitro-L-tyrosine | 3-Nitrotyrosine | Endogenous Metabolite |
3-Nitro-L-tyrosine (3-Nitrotyrosine) is the major product from the spontaneous reaction of peroxynitrite with tyrosine. Formation of nitrotyrosine can indicate the formation of peroxynitrite by a nitric oxide (NO)-depend... | |||
T3778 | 3'-Hydroxypuerarin | Pueraria glycoside,3'-hydroxy Puerarin | Others |
3'-Hydroxypuerarin (Pueraria glycoside) shows marked peroxynitrite. | |||
T21967 | MEG hemisulfate | Mercaptoethylguanidine hemisulfate | NOS |
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS i... | |||
T41242 | Uric acid sodium | Reactive Oxygen Species | |
Uric acid sodium, scavengers of oxygen radicals, is a potent and common antioxidant that helps maintain stable blood pressure and resist oxidative stress. Uric acid sodium, which removes reactive oxygen species (ROS) suc... | |||
T38164 | MnTBAP chloride | Mn(III)TBAP | |
MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory ... | |||
T2924 | Phloretin | Dihydronaringenin,NSC 407292,RJC 02792 | SGLT , transporter , Endogenous Metabolite |
Phloretin (NSC-407292) is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leav... | |||
T38324 | Coumarin Boronic Acid | ||
Coumarin boronic acid (CBA) is a fluorescent probe that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide.It reacts with peroxynitrite at an exponentially faster rate (k = 1.1 μM/s) than hydr... | |||
TN1796 | Brassicin | Isorhamnetin 7-O-glucoside | Others |
Isorhamnetin 7-O-glucoside has antioxidant activity, it showed the peroxynitrite and DPPH scavenging activities with IC50 values of 2.07 /- 0.17 and 13.3 microM, respectively. | |||
T35996 | FeTPPS | ||
Peroxynitrite is a highly reactive nitrogen species formed from the reaction of nitric oxide (NO) and superoxide.[1] FeTPPS is a ferric porphyrin complex that causes the decomposition of peroxynitrite by catalytic isomer... | |||
T27314 | Fe-TMPyP | ||
Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst. | |||
TN6608 | Cyanidin-3-O-arabinoside chloride | ||
Cyanidin-3-O-arabinoside chloride has antioxidant activity. It reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation and vascular dysfunction in HUVECs. | |||
T38325 | Coumarin Boronic Acid pinacolate ester | ||
Coumarin boronic acid pinacolate ester (CBE) is a more soluble form of coumarin boronic acid that can be used to detect peroxynitrite , hypochlorous acid, and hydrogen peroxide. Peroxynitrite oxidizes CBE into the fluore... | |||
T38933 | HKYellow-AM (6/12-mixture) | ||
HKYellow-AM (6/12-mixture) is a fluorogenic probe, which can be used for sensitive and specific detection of peroxynitrite. | |||
TN2545 | 1-Hydroxypinoresinol 1-O-glucoside | ROS | |
(+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/- 0.07 and 32.3 +/- 0.13 microM, respectively. | |||
T60530 | Mercaptoethylguanidine (MEG) (dihydrobromide) | ||
Mercaptoethylguanidine (MEG) dihydrobromide is a selective inducible nitric oxide synthase inhibitor and peroxynitrite scavenger with potential for inflammatory bowel diseases research. | |||
T35966 | Mn(III)TMPyP | ||
Mn(III)TMPyP is a manganese-porphyrin which acts as a superoxide dismutase (SOD) mimetic and peroxynitrite decomposition catalyst. SOD mimetics described to date are unstable and are capable of catalyzing undesired side-... | |||
T38646 | GKT136901 hydrochloride | GKT136901 hydrochloride | |
GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochlor... | |||
TN1834 | Kobusin | Others , NOS , NF-κB | |
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ... |