pain — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9530	W 36017		Others
	W36017 is an impurity of lidocaine with a PKA of 7.4 for blocking neurologic activity.		Others
T7688	4-Nonylphenylboronic acid		FAAH
	4-Nonylphenylboronic acid is a inhibitor of FAAH.		FAAH
T8538	ML382		Others
	ML382 is a potent and selective MrgX1 positive allosteric modulator(EC50 : 190 nM).		Others
TN2239	Strictosamide		ATPase , Potassium Channel , Sodium Channel , Parasite , Antifungal
	Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
T8410	ASP7663		TRP/TRPV Channel
	ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.		TRP/TRPV Channel
T7526	JNJ-17203212		TRP/TRPV Channel
	JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).		TRP/TRPV Channel
T9683	VX-150		Sodium Channel
	VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).		Sodium Channel
T60003	AC1-IN-1		Adenylyl cyclase
	AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).		Adenylyl cyclase
T7061	Duloxetine		Serotonin Transporter
	Duloxetine is an inhibitor of serotonin-norepinephrine reuptake(Ki of 4.6 nM),with treatment of major depressive disorder and generalized anxiety disorder.		Serotonin Transporter
T4S0537	Neoline	Bullatine B	Others
	Neoline (Bullatine B) shows analgesic/anti-inflammatory properties.		Others
T3S2312	Poncirin	Isosakuranetin-7-neohesperidoside	Apoptosis , Others
	1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...		Apoptosis , Others
T22360	MDR-652		TRP/TRPV Channel
	MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ...		TRP/TRPV Channel
T5513	RO-3		P2X Receptor
	RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor		P2X Receptor
T5460	Mofezolac		COX
	Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000		COX
T40045	Sivopixant	S-600918,Sivopixant	P2X Receptor
	Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .		P2X Receptor
TN6794	N-(3-methoxybenzyl)-octadecanamide		Others
	N-(3-methoxybenzyl)-octadecanamide deverts from Maca (Lepidium meyenii Walp.).		Others
T8975	PSB-SB-487		Cannabinoid Receptor
	PSB-SB-487 is antagonist of GPR55.		Cannabinoid Receptor
T4542	Clonixin	Clonixic acid	Others
	Clonixin (Clonixic acid) is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. This compound has been reported to block prostaglandin synthesis, and to block inward calcium currents.		Others
T4298	JNJ-47965567	JNJ-479655	P2X Receptor
	JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).		P2X Receptor
T6043	PF-3845		FAAH , Autophagy
	PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.		FAAH , Autophagy