methyltransferase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1904	SGI-1027	DNA Methyltransferase Inhibitor II,SGI1027	Apoptosis , DNA Methyltransferase
	SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT). The IC50 of SGI-1027(SGI1027) against DNMT1, DNMT3A, and DNMT3B are 6, 8, 7.5 μM, respectively.		Apoptosis , DNA Methyltransferase
T75389	Catechol O-methyltransferase
	Catechol O-methyltransferase (COMT) is a magnesium-dependent enzyme that mediates the transfer of methyl groups from S-adenosyl methionine to the hydroxyl group on dopamine, thus converting it to 3-methoxytyramine. COMT ...
T8548	Metoprine		Histone Methyltransferase , Antifolate , Histamine Receptor
	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.		Histone Methyltransferase , Antifolate , Histamine Receptor
T8381	Amodiaquine		Others , Histone Methyltransferase , Parasite
	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.		Others , Histone Methyltransferase , Parasite
T2097	C-7280948	C7280948	Histone Methyltransferase
	C-7280948 is a PRMT1 inhibitor.		Histone Methyltransferase
T6879	LLY-507	LLY507,LLY 507	Histone Methyltransferase
	LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.		Histone Methyltransferase
T8201	Gambogenic acid		Histone Methyltransferase
	Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.		Histone Methyltransferase
T3624	A-366	A 366,A366	Epigenetic Reader Domain , Histone Methyltransferase
	A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than 1,000-fold selective for G9a and GLP over the other 21 met...		Epigenetic Reader Domain , Histone Methyltransferase
T13780	MS1943		Apoptosis , Histone Methyltransferase
	MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).		Apoptosis , Histone Methyltransferase
T1841	UNC0379		Histone Methyltransferase
	UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.		Histone Methyltransferase
T7194	CM-272		Apoptosis , DNA Methyltransferase , Histone Methyltransferase
	CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
T6803	Chaetocin		Histone Methyltransferase , Antibacterial , Antibiotic
	Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.		Histone Methyltransferase , Antibacterial , Antibiotic
T2435	EPZ011989		Histone Methyltransferase
	EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase.		Histone Methyltransferase
TQ0100	AZ505		Histone Methyltransferase
	AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).		Histone Methyltransferase
T15194	EBI-2511		Histone Methyltransferase
	EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).		Histone Methyltransferase
T7089	SGC2085		Histone Methyltransferase
	SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).		Histone Methyltransferase
T15624	JNJ-64619178		Histone Methyltransferase
	JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.		Histone Methyltransferase
T1905	EPZ005687		Histone Methyltransferase
	EPZ005687 is a potent and selective inhibitor of EZH2.		Histone Methyltransferase
T6900	MS023		Histone Methyltransferase
	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.		Histone Methyltransferase
T3084	SGC707		Histone Methyltransferase
	SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.		Histone Methyltransferase