store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 79.00 | |
5 mg | In stock | $ 178.00 | |
10 mg | In stock | Inquiry | |
25 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 192.00 |
Description | JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer. |
Targets&IC50 | PRMT5:0.14 nM |
In vitro | JNJ-64619178 displays effective and broad inhibition of cellular growth. JNJ-64619178 binds simultaneously to the S-adenosylmethionine (SAM)- and protein substrate- binding pockets of the PRMT5/MEP50 complex with a pseudo-irreversible mode-of-action [1]. |
In vivo | In several non-small cell lung cancer and small cell lung cancer mouse xenograft models, JNJ-64619178 (p.o.) causes efficient inhibition of dimethylation of SMD1/3 proteins, components of the splicing machinery and direct substrates of the methylosome [1]. |
Molecular Weight | 483.36 |
Formula | C22H23BrN6O2 |
CAS No. | 2086772-26-9 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 120 mg/mL (248.26 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
JNJ-64619178 2086772-26-9 Chromatin/Epigenetic Histone Methyltransferase inhibit JNJ 64619178 Inhibitor JNJ64619178 Onametostat inhibitor