keratinocyte — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3855	Tracheloside		Estrogen Receptor/ERR , Phosphorylase
	Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).		Estrogen Receptor/ERR , Phosphorylase
TP1328	TB500		Others
	TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4.		Others
T10687	Casein Kinase II Inhibitor IV		Casein Kinase
	Casein Kinase II Inhibitor IV is an inducer of epidermal keratinocyte differentiation.		Casein Kinase
T20158	Phenformin	Debeone,N-Phenethylbiguanide,Insoral,BRN 1977317,Azucaps	Apoptosis
	Phenformin (BRN 1977317) is a biguanide compound with anticancer and anti-glycemic activity, inhibits skin tumor growth and promotes keratinocyte differentiation and apoptosis.		Apoptosis
T27710	K6PC-5	K6PC5,K6PC 5	S1P Receptor
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated ...		S1P Receptor
T6696	Tazarotene	Tazorac,AGN 190168,Zorac	Retinoid Receptor , Autophagy
	Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati...		Retinoid Receptor , Autophagy
TP2308	TB500 acetate(885340-08-9 free base)	Frag17-23 Acetate,TB500 Acetate	Others
	TB500 acetate(885340-08-9 free base) (Frag17-23 Acetate) is a synthetic version of an active region of thymosin β4. It promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, col...		Others
TP2497	Myristoyl Tetrapeptide-12 Acetate	Myristoyl Tetrapeptide-12 Acetate(959610-24-3 Free base)	Others
	Myristoyl Tetrapeptide-12 Acetate (Myristoyl Tetrapeptide-12 Acetate (959610-24-3 Free base)) , the reaction product of myristic acid and Tetrapeptide-12, is a peptide stimulating hair and eyelash growth and enhancing th...		Others
T37753	Aureusimine B		Cysteine Protease , Antibacterial
	Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide syntheta...		Cysteine Protease , Antibacterial
T26958	CAY10583	CAY 10583,CAY-10583
	CAY10583 is an agonist of leukotriene B4 receptor type 2 (BLT2). CAY10583 directly promotes keratinocyte migration and indirectly enhances fibroblast proliferation by increasing keratinocyte production of bFGF1 and TGF-β...
T30526	BMS-480404	BMS 480404,BMS480404,UNII-T78485CEYD
	BMS-480404 is an effective small molecule inhibitor, which can bind to human keratinocyte fatty acid-binding protein.
T62055	NVS-BET-1
	NVS-BET-1 is a BET bromodomain inhibitor. NVS-BET-1 can regulate keratinocyte plasticity.
T81330	Q-Peptide
	Q-Peptide, an angiopoietin-1 derived peptide (QHREDGS), enhances keratinocyte migration, thereby facilitating wound healing in a diabetic mouse model, and accelerates wound closure [1].
T37158	8(S)-HETE
	8(S)-HETE is a major lipoxygenase product in PMA-treated murine epidermis. It activates mouse keratinocyte protein kinase C with an IC50 of 100 μM. 8(S)-HETE also activates PPARα selectively at concentrations as low as 0...
T35524	(1S)-Calcitriol
	(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3), a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), exerts potent actions through vitamin D receptor (VDR) activation, including the inhibition of keratin...
T10687L	Casein Kinase II Inhibitor IV Hydrochloride	Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base)	Others
	Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation that lead to novel therapeutic approaches for the treatment of skin hyperproliferative disorders.		Others
T61996	Antiproliferative agent-6
	Antiproliferative agent-6 (compound 8a) is a potent antitumor compound. Antiproliferative agent-6 shows antiproliferative activity. Antiproliferative agent-6 inhibits cancer cell lines HCT116, MCF-7, H460 and non-tumor a...
T37547	Trans-Urocanic Acid
	trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes ...
T36531	PAR2 (1-6) (mouse, rat)	PAR2 (1-6) (mouse, rat)
	PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 3...
T35671	Salazinic Acid
	Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30...