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Casein Kinase II Inhibitor IV Hydrochloride

Catalog No. T10687L CAS 2320347-54-2

Synonyms: Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base)

Casein Kinase II Inhibitor IV Hydrochloride is a small-molecule inducer of epidermal keratinocyte differentiation that lead to novel therapeutic approaches for the treatment of skin hyperproliferative disorders.

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Casein Kinase II Inhibitor IV Hydrochloride Chemical Structure

Casein Kinase II Inhibitor IV Hydrochloride, CAS 2320347-54-2

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,520.00
50 mg	10-14 weeks	$ 1,980.00
100 mg	10-14 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description

In vitro

Treatment with Casein Kinase II Inhibitor IV enhances early differentiation in human epidermal keratinocytes (NHEKs), evidenced by increased keratins 1 and 10 expression at 48 hours. Levels of IVL and TGM also rise at 72 hours and remain elevated at 96 hours. Furthermore, this treatment induces expression of loricrin, a marker of terminal differentiation, at later stages. mRNA expression analysis corroborates these findings, showing early upregulation of keratinocyte differentiation marker genes keratin 1 (5.4-fold) and keratin 10 (5.4-fold) at 12 and 24 hours, while genes marking terminal differentiation, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are significantly increased at 36 and 48 hours. These consistent results underscore Casein Kinase II Inhibitor IV's capacity to drive the differentiation of epidermal progenitor cells into terminally differentiated keratinocytes [1].

Synonyms	Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base)
Molecular Weight	465.93
Formula	C24H24ClN5O3
CAS No.	2320347-54-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Hong J, et al. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation. ACS Chem Biol. 2007 Mar 20;2(3):171-5.

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Keywords

Casein Kinase II Inhibitor IV Hydrochloride 2320347-54-2 Others Casein Kinase II Inhibitor IV Hydrochloride (863598-09-8 free base) 863598-09-8 free base 863598-09-8 inhibitor inhibit

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