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Casein Kinase II Inhibitor IV

Catalog No. T10687 CAS 863598-09-8

Casein kinase II inhibitor IV is an effective small molecule inducer, which can be used to induce epidermal keratinocyte differentiation.

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Casein Kinase II Inhibitor IV Chemical Structure

Casein Kinase II Inhibitor IV, CAS 863598-09-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 455.00
25 mg	In stock	$ 753.00
50 mg	In stock	$ 1,060.00
100 mg	In stock	$ 1,430.00
500 mg	In stock	$ 2,860.00
1 mL * 10 mM (in DMSO)	In stock	$ 317.00

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Purity: 99.32%

Purity: 98.81%

Biological Description

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Description

Casein kinase II inhibitor IV is an effective small molecule inducer, which can be used to induce epidermal keratinocyte differentiation.

In vitro

Treatment with Casein Kinase II Inhibitor IV on human epidermal keratinocytes (NHEKs) enhances early differentiation markers, keratins 1 and 10, at 48 hours, while increasing levels of IVL and TGM at 72 hours, sustained through 96 hours. This inhibitor also prompts the expression of loricrin, a terminal differentiation marker, at subsequent time points. Correspondingly, mRNA expression analysis confirms upregulation of early differentiation marker genes, specifically keratin 1 and keratin 10 by 5.4-fold at 12 and 24 hours. Late-differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), exhibit increased expression at 36 and 48 hours in NHEKs treated with Casein Kinase II Inhibitor IV.

Molecular Weight	429.47
Formula	C24H23N5O3
CAS No.	863598-09-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (69.85 mM)

References and Literature

1. Hong J, et al. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation. ACS Chem Biol. 2007 Mar 20;2(3):171-5.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

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ON 108600 MLN8054 SR-3029 PI-828 (E/Z)-GO289 XL413 Casein kinase 1δ-IN-3 Longdaysin

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Casein Kinase II Inhibitor IV 863598-09-8 Metabolism Stem Cells Casein Kinase Inhibitor inhibit inhibitor

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