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Search Results for " irritable "

20

Compounds

Cat No. Product Name Synonyms Targets
T9420 Prifinium bromide Others
Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action.
T1460 Dicyclomine hydrochloride AChR
Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.
T5491 GSK3179106 c-RET
GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM
T13385 Zamifenacin fumarate UK-76654 fumarate AChR
Zamifenacin fumarate (UK-76654 fumarate) is a potent and gut-selective antagonist of muscarinic M3 receptor.
T4691 Asimadoline hydrochloride EMD-61753 hydrochloride Opioid Receptor
Asimadoline hydrochloride (EMD-61753 hydrochloride) is a κ-opioid receptor agonist potentially for the treatment of pruritus. Asimadoline hydrochloride has also been shown to be used in the treatment of irritable bowel s...
T1551 Tegaserod maleate HTF-919,SDZ-HTF-919 5-HT Receptor
Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ...
T4633 Asimadoline EMD-61753 Opioid Receptor
Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline...
T4562L Ramosetron hydrochloride YM 060,YM-060,YM060 5-HT Receptor
Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.
T38507 Renzapride BRL 24924 5-HT Receptor
Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS).
T28043L Minesapride 5-HT Receptor
Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation.
T11852 Linaclotide Guanylate cyclase
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist.
T22577 Antalarmin hydrochloride CRFR , Immunology/Inflammation related
Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel...
T60680 Tegaserod 5-HT Receptor
Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable ...
T12970 Solabegron GW 427353 Adrenergic Receptor
Solabegron (GW 427353) is a selective agonist of β3-adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR(EC50 : 22 nM). It is used for treatment of overactive bladd...
T69984 Ticalopride 5-HT Receptor
Ticalopride is a 5-HT3 receptor agonist used in the treatment of digestive disorders, orofacial disorders, otorhinolaryngologic disorders, and may be used in the study of bulimia nervosa, gastroesophageal reflux, and irr...
T0786 Clidinium bromide Ro 2-3773 AChR
Clidinium bromide (Ro 2-3773) , a synthetic anticholinergic agent, has been shown in experimental and clinical researchers to have a pronounced antisecretory and antispasmodic effect on the gastrointestinal tract. It can...
T4562 Ramosetron 5-HT Receptor
Ramosetron is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondanse...
T0918 Trimebutine Mebutin Opioid Receptor
Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl...
T30936 Cilansetron Hydrochloride KC-9946,KC9946,KC 9946
Cilansetron Hydrochloride can be used for irritable Bowel Syndrome (IBS) with Diarrhea Predominance.
T10289 Alosetron ((Z)-2-butenedioate) GR 68755 ((Z)-2-butenedioate),GR 68755X ((Z)-2-butenedioate) Others
Alosetron (GR 68755) (Z)-2-butenedioate is a Serotonin 5HT3-receptor antagonist that is used in the treatment of irritable bowel syndrome.
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