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Ramosetron hydrochloride

Catalog No. T4562L CAS 132907-72-3

Synonyms: YM 060, YM-060, YM060

Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.

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Ramosetron hydrochloride Chemical Structure

Ramosetron hydrochloride, CAS 132907-72-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 32.00
10 mg	In stock	$ 43.00
25 mg	In stock	$ 71.00
50 mg	In stock	$ 101.00
100 mg	In stock	$ 179.00
200 mg	In stock	$ 269.00
1 mL * 10 mM (in DMSO)	In stock	$ 42.00

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Purity: 99.96%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ramosetron hydrochloride (YM-060) is a serotonin 5-HT3 receptor antagonist. It is used to treat diarrhea-predominant irritable bowel syndrome and nausea.

Synonyms	YM 060, YM-060, YM060
Molecular Weight	315.8
Formula	C17H18ClN3O
CAS No.	132907-72-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32 mg/mL (101.33 mM), Sonication and heating are recommended.

References and Literature

1. Kim TK, Cho YJ, Lim CW, Min JJ, Choi EK, Hong DM, Jeon Y. Effect of ramosetron on QTc interval: a randomised controlled trial in patients undergoing off-pump coronary artery bypass surgery. BMC Anesthesiol. 2016 Aug 3;16(1):56. doi: 10.1186/s12871-016-0222-1. PubMed PMID: 27488394; PubMed Central PMCID: PMC4972982. 2. Joo J, Park S, Park HJ, Shin SY. Ramosetron versus ondansetron for postoperative nausea and vomiting in strabismus surgery patients. BMC Anesthesiol. 2016 Jul 22;16(1):41. doi: 10.1186/s12871-016-0210-5. PubMed PMID: 27449404; PubMed Central PMCID: PMC4957928. 3. Lee YH, Seo JH, Min KT, Lim YJ, Jeong SW, Lee EK, Choi BM, Noh GJ. Population pharmacokinetics and prophylactic anti-emetic efficacy of ramosetron in surgical patients. Br J Clin Pharmacol. 2016 Sep;82(3):762-72. doi: 10.1111/bcp.13010. Epub 2016 Jun 8. PubMed PMID: 27195435. 4. Song HJ, Seo HJ, Son H. Comparative effectiveness of ramosetron for preventing chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis. Eur J Clin Pharmacol. 2016 Aug 15. [Epub ahead of print] Review. PubMed PMID: 27526189.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ramosetron hydrochloride 132907-72-3 GPCR/G Protein Neuroscience 5-HT Receptor Serotonin Receptor Ramosetron YM 060 YM-060 Inhibitor inhibit 5-hydroxytryptamine Receptor Ramosetron Hydrochloride YM060 inhibitor

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